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Structure of PDB 3ifa Chain A

Receptor sequence >3ifaA (length=326) Species: 9606 (Homo sapiens) [Search protein sequence] TDMLTLTRYVMEKGRQAKGTGELTQLLNSMLTAIKAISSAVRKAGLAHLY GIAGSVNVDQVKKLDVLSNSLVINMLQSSYSTCVLVSEENKDAIITAKEK RGKYVVCFDPLDGSSNIDCLASIGTIFAIYRKTSDEPSEKDALQCGRNIV AAGYALYGSATLVALSTGQGVDLFMLDPALGEFVLVEKDVKIKKKGKIYS LNEGYAKYFDAATTEYVQKKKFPEDGSAPYGARYVGSMVADVHRTLVYGG IFLYPANQKSPKGKLRLLYECNPVAYIIEQAGGLATTGTQPVLDVKPEAI HQRVPLILGSPEDVQEYLTCVQKNQA

3D structure PDB 3ifa Structure of E69Q mutant of human muscle fructose-1,6-bisphosphatase Chain A Resolution 1.93 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) D74 E97 E98 D118 L120 D121 E280 Catalytic site (residue number reindexed from 1) D65 E88 E89 D109 L111 D112 E270 Enzyme Commision number 3.1.3.11: fructose-bisphosphatase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 AMP A G21 A24 T27 L30 K112 Y113 R140 T177 G14 A17 T20 L23 K103 Y104 R131 T167

Gene Ontology Molecular Function GO:0005515 protein binding GO:0016787 hydrolase activity GO:0016791 phosphatase activity GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity GO:0042578 phosphoric ester hydrolase activity GO:0042802 identical protein binding GO:0046872 metal ion binding

	Biological Process
GO:0005975	carbohydrate metabolic process
GO:0005986	sucrose biosynthetic process
GO:0006000	fructose metabolic process
GO:0006002	fructose 6-phosphate metabolic process
GO:0006094	gluconeogenesis
GO:0030388	fructose 1,6-bisphosphate metabolic process

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0030018	Z disc
GO:0070062	extracellular exosome
GO:0070161	anchoring junction

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