Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

Structure of PDB 3hps Chain A

Receptor sequence >3hpsA (length=575) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] TIVKPAGPPRVGQPSWNPQRASSMPVNRYRPFAEEVEPIRLRNRTWPDRV IDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSA SQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVH FYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSP ESYTGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSI EWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGE RTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYG GDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRD VGRTYEAVIKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIEVSPKEMWDA FAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNG PLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIATSKTV WGVGIAPSITTASLRAVVSAVNRAA

3D structure PDB 3hps Probing the active site of M. tuberculosis LeuA Chain A Resolution 1.8 Å 3D structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Enzyme Commision number 2.3.3.13: 2-isopropylmalate synthase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 LEU A D563 A565 Q566 P625 I627 D530 A532 Q533 P557 I559 BS02 ZN A D81 H285 H287 D64 H268 H270 BS03 COI A R80 H167 Y169 P252 T254 H285 H287 R63 H150 Y152 P235 T237 H268 H270 BS04 LEU A G533 P534 L535 A536 G500 P501 L502 A503

Gene Ontology Molecular Function GO:0000287 magnesium ion binding GO:0003824 catalytic activity GO:0003852 2-isopropylmalate synthase activity GO:0003985 acetyl-CoA C-acetyltransferase activity GO:0005515 protein binding GO:0008270 zinc ion binding GO:0016740 transferase activity GO:0030145 manganese ion binding GO:0030955 potassium ion binding GO:0046872 metal ion binding GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer

	Biological Process
GO:0009098	L-leucine biosynthetic process
GO:0019752	carboxylic acid metabolic process

	Cellular Component
GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005886	plasma membrane

View graph for Molecular Function

View graph for Biological Process

View graph for Cellular Component