BioLiP

Structure of PDB 2qpy Chain A

Receptor sequence

>2qpyA (length=248) Species: 10090 (Mus musculus) [Search protein sequence]

PIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAK
ALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVF
NEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDG
LKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIA
RELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHT

3D structure

PDB

2qpy A surface on the androgen receptor that allosterically regulates coactivator binding.

Chain

Resolution

2.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	V716 K720 Q733 M734 Q738 M894	V46 K50 Q63 M64 Q68 M224
BS02	DHT	A	L704 N705 M745 M749 F764 T877	L34 N35 M75 M79 F94 T207	BindingDB: EC50=3.98nM,IC50=1.000000nM
BS03	4HY	A	G724 N727 F826 L830 N833 Y834 R840	G54 N57 F156 L160 N163 Y164 R170

External links

PDB	RCSB:2qpy, PDBe:2qpy, PDBj:2qpy
PDBsum	2qpy
PubMed	17911242
UniProt	P19091\|ANDR_MOUSE Androgen receptor (Gene Name=Ar)

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