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Structure of PDB 1w25 Chain A

Receptor sequence >1w25A (length=454) Species: 190650 (Caulobacter vibrioides CB15) [Search protein sequence] SARILVVDDIEANVRLLEAKLTAEYYEVSTAMDGPTALAMAARDLPDIIL LDVMMPGMDGFTVCRKLKDDPTTRHIPVVLITALDGRGDRIQGLESGASD FLTKPIDDVMLFARVRSLTRFKLVIDELRQREASGRRMGVIAGAAARLDG LGGRVLIVDDNERQAQRVAAELGVEHRPVIESDPEKAKISAGGPVDLVIV NAAAKNFDGLRFTAALRSEERTRQLPVLAMVDPDDRGRMVKALEIGVNDI LSRPIDPQELSARVKTQIQRKRYTDYLRNNLDHSLELAVTDQLTGLHNRR YMTGQLDSLVKRATLGGDPVSALLIDIDFFKKINDTFGHDIGDEVLREFA LRLASNVRAIDLPCRYGGEEFVVIMPDTALADALRIAERIRMHVSGSPFT VAHGREMLNVTISIGVSATAGEGDTPEALLKRADEGVYQAKASGRNAVVG KAAH

3D structure PDB 1w25 Structural Basis of Activity and Allosteric Control of Diguanylate Cyclase Chain A Resolution 2.7 Å 3D structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Enzyme Commision number 2.7.7.65: diguanylate cyclase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 MG A D9 D10 D53 M55 D8 D9 D52 M54 Manual survey: Ki=0.5uM (15569936) BS02 C2E A N335 D344 G369 E370 N334 D343 G368 E369 Manual survey: Ki=0.5uM (15569936) PDBbind-CN: -logKd/Ki=6.30,Ki=0.5uM BS03 C2E A R178 R359 D362 D383 I387 R390 R177 R358 D361 D382 I386 R389 Manual survey: Ki=0.5uM (15569936) PDBbind-CN: -logKd/Ki=6.30,Ki=0.5uM BS04 C2E A R148 V175 R178 S356 R359 A360 R390 R147 V174 R177 S355 R358 A359 R389 Manual survey: Ki=0.5uM (15569936) PDBbind-CN: -logKd/Ki=6.30,Ki=0.5uM

Gene Ontology Molecular Function GO:0005525 GTP binding GO:0016740 transferase activity GO:0046872 metal ion binding GO:0052621 diguanylate cyclase activity

	Biological Process
GO:0000160	phosphorelay signal transduction system
GO:0030154	cell differentiation
GO:0043709	cell adhesion involved in single-species biofilm formation
GO:1902201	negative regulation of bacterial-type flagellum-dependent cell motility

	Cellular Component
GO:0005737	cytoplasm
GO:0005886	plasma membrane

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