Structure of PDB 1rbz Chain A

Receptor sequence

>1rbzA (length=200) Species: 9606 (Homo sapiens) [Search protein sequence]

ARVAVLISGTGSNLQALIDSTREPNSSAQIDIVISNKAAVAGLDKAERAG
IPTRVINHKLYKNRVEFDSAIDLVLEEFSIDIVCLAGFMRILSGPFVQKW
NGKMLNIHPSLLPSFKGSNAHEQALETGVTVTGCTVHFVAEDVDAGQIIL
QEAVPVKRGDTVATLSERVKLAEHKIFPAALQLVASGTVQLGENGKICWV

3D structure

PDB

1rbz Human GAR Tfase complex structure

Chain

Resolution

2.1 Å

3D
structure

Catalytic site residues are labeled in the structure
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Enzymatic activity

Catalytic site (original residue number in PDB)	N106 H108 T135 D144
Catalytic site (residue number reindexed from 1)	N106 H108 T135 D144
Enzyme Commision number	2.1.2.2: phosphoribosylglycinamide formyltransferase 1. 6.3.3.1: phosphoribosylformylglycinamidine cyclo-ligase. 6.3.4.13: phosphoribosylamine--glycine ligase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	KT5	A	T10 G11 S12 R64 L85 M89 R90 I91 L92 N106 H108 G117 S118 V139 A140 V143 D144 E173	T10 G11 S12 R64 L85 M89 R90 I91 L92 N106 H108 G117 S118 V139 A140 V143 D144 E173	MOAD: Ki=4nM

Gene Ontology

	Molecular Function
GO:0004644	phosphoribosylglycinamide formyltransferase activity

	Biological Process
GO:0006189	'de novo' IMP biosynthetic process
GO:0009058	biosynthetic process

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1rbz, PDBe:1rbz, PDBj:1rbz
PDBsum	1rbz
PubMed
UniProt	P22102\|PUR2_HUMAN Trifunctional purine biosynthetic protein adenosine-3 (Gene Name=GART)

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