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Structure of PDB 1p77 Chain A

Receptor sequence >1p77A (length=265) Species: 727 (Haemophilus influenzae) [Search protein sequence] MDLYAVWGNPIAQSKSPLIQNKLAAQTHQTMEYIAKLGDLDAFEQQLLAF FEEGAKGCNITSPFKERAYQLADEYSQRAKLAEACNTLKKLDDGKLYADN TDGIGLVTDLQRLNWLRPNQHVLILGAGGATKGVLLPLLQAQQNIVLANR TFSKTKELAERFQPYGNIQAVSMDSIPLQTYDLVINATSASVDAEILKLG SAFYDMQYAKGTDTPFIALCKSLGLTNVSDGFGMLVAQAAHSFHLWRGVM PDFVSVYEQLKKAML

3D structure PDB 1p77 The crystal structure of shikimate dehydrogenase (AroE) reveals a unique NADPH binding mode Chain A Resolution 1.95 Å 3D structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Enzyme Commision number 1.1.1.25: shikimate dehydrogenase (NADP(+)).

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 ATR A G126 G128 G129 A130 N149 R150 T151 K154 T188 S189 A190 G126 G128 G129 A130 N149 R150 T151 K154 T188 S189 A190

Gene Ontology Molecular Function GO:0004764 shikimate 3-dehydrogenase (NADP+) activity GO:0016491 oxidoreductase activity GO:0050661 NADP binding

	Biological Process
GO:0008652	amino acid biosynthetic process
GO:0009073	aromatic amino acid family biosynthetic process
GO:0009423	chorismate biosynthetic process
GO:0019632	shikimate metabolic process

	Cellular Component
GO:0005829	cytosol

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