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Structure of PDB 1o6r Chain A

Receptor sequence >1o6rA (length=619) Species: 405212 (Alicyclobacillus acidocaldarius) [Search protein sequence] AYARTLDRAVEYLLSCQKDEGYWWGPLLSNVTMEAEYVLLCHILDRVDRD RMEKIRRYLLHEQREDGTWALYPGGPPDLDTTIEAYVALKYIGMSRDEEP MQKALRFIQSQGGIESSRVFTRMWLALVGEYPWEKVPMVPPEIMFLGKRM PLNIYEFGSWARATVVALSIVMSRQPVFPLPERARVPELYETDVPPRRRG AKGGGGWIFDALDRALHGYQKLSVHPFRRAAEIRALDWLLERQAGDGSWG GIQPPWFYALIALKILDMTQHPAFIKGWEGLELYGVELDYGGWMFQASIS PVWDTGLAVLALRAAGLPADHDRLVKAGEWLLDRQITVPGDWAVKRPNLK PGGFAFQFDNVYYPDVDDTAVVVWALNTLRLPDERRRRDAMTKGFRWIVG MQSSNGGWGAYDVDNTSDLPNHIPFCDFGEVTDPPSEDVTAHVLECFGSF GYDDAWKVIRRAVEYLKREQKPDGSWFGRWGVNYLYGTGAVVSALKAVGI DTREPYIQKALDWVEQHQNPDGGWGEDCRSYEDPAYAGKGASTPSQTAWA LMALIAGGRAESEAARRGVQYLVETQRPDGGWDEPYYTGTGFPGDFYLGY TMYRHVFPTLALGRYKQAI

3D structure PDB 1o6r Binding Structures and Potencies of Oxidosqualene Cyclase Inhibitors with the Homologous Squalene-Hopene Cyclase Chain A Resolution 2.7 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) E45 E93 R127 W169 Q262 W312 F365 D374 D376 D377 Y420 H451 W489 Y495 F601 F605 Y609 Catalytic site (residue number reindexed from 1) E36 E84 R118 W160 Q253 W303 F356 D365 D367 D368 Y411 H442 W480 Y486 F592 F596 Y600 Enzyme Commision number 4.2.1.129: squalene--hopanol cyclase. 5.4.99.17: squalene--hopene cyclase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 C8E A R251 Y371 R242 Y362 BS02 R19 A F129 P263 W312 D374 W489 F601 F605 Y609 F120 P254 W303 D365 W480 F592 F596 Y600 PDBbind-CN: -logKd/Ki=7.10,IC50=80nM

Gene Ontology Molecular Function GO:0016829 lyase activity GO:0016853 isomerase activity GO:0016866 intramolecular transferase activity GO:0051007 squalene-hopene cyclase activity

	Biological Process
GO:0008610	lipid biosynthetic process
GO:0016104	triterpenoid biosynthetic process

	Cellular Component
GO:0005811	lipid droplet
GO:0005886	plasma membrane

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