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Structure of PDB 1mxa Chain A

Receptor sequence >1mxaA (length=377) Species: 562 (Escherichia coli) [Search protein sequence] AKHLFTSESVSEGHPDKIADQISDAVLDAILEQDPKARVACETYVKTGMV LVGGEITTSAWVDIEEITRNTVREIGYVHSDMGFDANSCAVLSAIGKQSP DRADPLEQGAGDQGLMFGYATNETDVLMPAPITYAHRLVQRQAEVRKNGT LPWLRPDAKSQVTFQYDDGKIVGIDAVVLSTQHSEEIDQKSLQEAVMEEI IKPILPAEWLTSATKFFINPTGRFVIGGPMGDCGLTGRKIIVDTYGGMAR HGGGAFSGKDPSKVDRSAAYAARYVAKNIVAAGLADRCEIQVSYAIGVAE PTSIMVETFGTEKVPSEQLTLLVREFFDLRPYGLIQMLDLLHPIYKETAA YGHFGREHFPWEKTDKAQLLRDAAGLK

3D structure PDB 1mxa Structure and function of S-adenosylmethionine synthetase: crystal structures of S-adenosylmethionine synthetase with ADP, BrADP, and PPi at 28 angstroms resolution. Chain A Resolution 2.8 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) H14 D16 K17 E42 E55 K165 F230 D238 C239 R244 K245 K265 K269 D271 Catalytic site (residue number reindexed from 1) H14 D16 K17 E42 E55 K159 F224 D232 C233 R238 K239 K259 K263 D265 Enzyme Commision number 2.5.1.6: methionine adenosyltransferase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 PO4 A A261 K265 A255 K259

Gene Ontology Molecular Function GO:0000287 magnesium ion binding GO:0004478 methionine adenosyltransferase activity GO:0005515 protein binding GO:0005524 ATP binding GO:0016740 transferase activity GO:0030955 potassium ion binding GO:0042802 identical protein binding GO:0046872 metal ion binding

	Biological Process
GO:0006556	S-adenosylmethionine biosynthetic process
GO:0006730	one-carbon metabolic process
GO:0033353	S-adenosylmethionine cycle

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

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