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Structure of PDB 1km1 Chain A

Receptor sequence >1km1A (length=212) Species: 145262 (Methanothermobacter thermautotrophicus) [Search protein sequence] VMNRLILAMDLMNRDDALRVTGEVREYIDTVKIGYPLVLSEGMDIIAEFR KRFGCRIIADFKVADIPETNEKICRATFKAGADAIIVHGFPGADSVRACL NVAEEMGREVFLLTEMAHPGAEMFIQGAADEIARMGVDLGVKNYVGPSTR PERLSRLREIIGQDSFLISPGVGAQGGDPGETLRFADAIIVGRSIYLADN PAAAAAGIIESI

3D structure PDB 1km1 Mapping the active site-ligand interactions of orotidine 5'-monophosphate decarboxylase by crystallography. Chain A Resolution 1.6 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) K42 D70 K72 D75 Catalytic site (residue number reindexed from 1) K32 D60 K62 D65 Enzyme Commision number 4.1.1.23: orotidine-5'-phosphate decarboxylase.

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 UP6 A D20 K42 K72 M126 P180 Q185 G202 R203 D10 K32 K62 M116 P170 Q175 G192 R193 BindingDB: Ki=12400nM BS02 UP6 A D75 I76 T79 D65 I66 T69 BindingDB: Ki=12400nM

Gene Ontology Molecular Function GO:0004590 orotidine-5'-phosphate decarboxylase activity GO:0016831 carboxy-lyase activity

	Biological Process
GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process
GO:0006221	pyrimidine nucleotide biosynthetic process
GO:0044205	'de novo' UMP biosynthetic process

	Cellular Component
GO:0005829	cytosol

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