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Structure of PDB 1hwl Chain A

Receptor sequence >1hwlA (length=407) Species: 9606 (Homo sapiens) [Search protein sequence] PRPNEECFLSDAEIIQLVNAKHIPAYKLETLIETHERGVSIRRQLLSKKL SEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGVAGPLCLDEKEFQV PMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRLPRACDSA EVKAWLETSEGFAVIKEAFDSTSRFARLQKLHTSIAGRNLYIRFQSRSGD AMGMNMISKGTEKALSKLHEYFPEMQILAVSGNYCTDKKPAAINWIEGRG KSVVCEAVIPAKVVREVLKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHA ANIVTAIYIACGQDAAQNVGSSNCITLMEASGPTNEDLYISCTMPSIEIG TVGGGTNLLPQQACLQMLGVQGACKDNPGENARQLARIVCGTVMAGELSL MAALAAG

3D structure PDB 1hwl Structural mechanism for statin inhibition of HMG-CoA reductase. Chain A Resolution 2.1 Å 3D structure Catalytic site residues are labeled in the structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Catalytic site (original residue number in PDB) E559 K691 D767 Catalytic site (residue number reindexed from 1) E106 K238 D314 Enzyme Commision number 1.1.1.34: hydroxymethylglutaryl-CoA reductase (NADPH).

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 ADP A Y479 N529 Y26 N76 BS02 ADP A A564 N567 R568 K722 A111 N114 R115 K269 BS03 FBI A R590 S684 D690 K691 K692 R137 S231 D237 K238 K239 MOAD: ic50=5nM BS04 FBI A E559 C561 L562 S565 K735 A751 L853 A856 E106 C108 L109 S112 K282 A298 L400 A403 MOAD: ic50=5nM

Gene Ontology Molecular Function GO:0004420 hydroxymethylglutaryl-CoA reductase (NADPH) activity GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0050661 NADP binding

	Biological Process
GO:0008299	isoprenoid biosynthetic process
GO:0015936	coenzyme A metabolic process

	Cellular Component
GO:0005789	endoplasmic reticulum membrane

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