Structure of PDB 1emh Chain A

Receptor sequence

>1emhA (length=223) Species: 9606 (Homo sapiens) [Search protein sequence]

MEFFGESWKKHLSGEFGKPYFIKLMGFVAEERKHYTVYPPPHQVFTWTQM
CDIKDVKVVILGQDPYHGPNQAHGLCFSVQRPVPPPPSLENIYKELSTDI
EDFVHPGHGDLSGWAKQGVLLLNAVLTVRAHQANSHKERGWEQFTDAVVS
WLNQNSNGLVFLLWGSYAQKKGSAIDRKRHHVLQTAHPSPLSVYRGFFGC
RHFSKTNELLQKSGKKPIDWKEL

3D structure

PDB

1emh Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects.

Chain

Resolution

1.8 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.2.2.27: uracil-DNA glycosylase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	A	Q144 D145 Y147 H148 C157 F158 P168 S169 N204 G246 S247 H268 S270 P271 L272 S273 R276	Q63 D64 Y66 H67 C76 F77 P87 S88 N123 G165 S166 H187 S189 P190 L191 S192 R195

Gene Ontology

	Molecular Function
GO:0004844	uracil DNA N-glycosylase activity
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds

	Biological Process
GO:0006281	DNA repair
GO:0006284	base-excision repair

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:1emh, PDBe:1emh, PDBj:1emh
PDBsum	1emh
PubMed	10805771
UniProt	P13051\|UNG_HUMAN Uracil-DNA glycosylase (Gene Name=UNG)

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