Structure of PDB 1c9b Chain A

Receptor sequence

>1c9bA (length=207) Species: 9606 (Homo sapiens) [Search protein sequence]

SDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRANDAI
ASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSVDLI
TTGDFMSRFCSNLCLPKQVQMAATHIARKAVELDLVPGRSPISVAAAAIY
MASQASAEKRTQKEIGDIAGVADVTIRQSYRLIYPRAPDLFPTDFKFDTP
VDKLPQL

3D structure

PDB

1c9b Structural basis of preinitiation complex assembly on human pol II promoters.

Chain

Resolution

2.65 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

2.3.1.48: histone acetyltransferase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	dna	A	K189 K196	K80 K87
BS02	dna	A	K152 G153 R154 G247 R248 S249 S252 A281 T284	K43 G44 R45 G138 R139 S140 S143 A172 T175
BS03	dna	A	S110 Y146 G153 A155 N156	S1 Y37 G44 A46 N47
BS04	dna	A	T270 Q271 K272 R286	T161 Q162 K163 R177

Gene Ontology

	Molecular Function
GO:0017025	TBP-class protein binding

	Biological Process
GO:0006352	DNA-templated transcription initiation
GO:0070897	transcription preinitiation complex assembly

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Molecular Function

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Biological Process

External links

PDB	RCSB:1c9b, PDBe:1c9b, PDBj:1c9b
PDBsum	1c9b
PubMed	10619841
UniProt	Q00403\|TF2B_HUMAN Transcription initiation factor IIB (Gene Name=GTF2B)

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