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Structure of PDB 8pw6 Chain 1

Receptor sequence >8pw61 (length=430) Species: 10090 (Mus musculus) [Search protein sequence] KTSFGSLKDEDRIFTNLYGRHDWRLKGALRRGDWYKTKEILLKGPDWILG EMKTSGLRGRGGAGFPTGLKWSFMNKPSDGRPKYLVVNADEGEPGTCKDR EIMRHDPHKLVEGCLVGGRAMGARAAYIYIRGEFYNEASNLQVAIREAYE AGLIGKNACGSDYDFDVFVVRGAGAYICGEETALIESIEGKQGKPRLKPP FPADVGVFGCPTTVANVETVAVSPTICRRGGTWFAGFGRERNSGTKLFNI SGHVNHPCTVEEEMSVPLKELIEKHAGGVTGGWDNLLAVIPGGSSTPLIP KSVCETVLMDFDALVQAQTGLGTAAVIVMDRSTDIVKAIARLIEFYKHES CGQCTPCREGVDWMNKVMARFVKGDARPAEIDSLWEISKQIEGHTICALG DGAAWPVQGLIRHFRPELEDRMQRFAQQHR

3D structure PDB 8pw6 SCAF1 drives the compositional diversity of mammalian respirasomes. Chain 1 Resolution 3.3 Å 3D structure [Spin on] [Spin off] [Reset orientation] [High quality] [Low quality] [White background] [Black background] [Download] [Download structure with residue number starting from 1]

Enzymatic activity Enzyme Commision number 7.1.1.2: NADH:ubiquinone reductase (H(+)-translocating).

Interaction with ligand Site # Ligand Ligand chain Binding residues on receptor (original residue number in PDB) Binding residues on receptor (residue number reindexed from 1) Binding affinity BS01 FMN 1 G67 G69 K78 N96 D98 E99 G100 Y184 G187 E188 V222 A223 N224 A406 L407 G59 G61 K70 N88 D90 E91 G92 Y176 G179 E180 V214 A215 N216 A398 L399 BS02 SF4 1 I185 P203 S358 C359 G360 Q361 C362 C365 T403 I404 C405 L407 I177 P195 S350 C351 G352 Q353 C354 C357 T395 I396 C397 L399

Gene Ontology Molecular Function GO:0005515 protein binding GO:0008137 NADH dehydrogenase (ubiquinone) activity GO:0010181 FMN binding GO:0016491 oxidoreductase activity GO:0046872 metal ion binding GO:0051287 NAD binding GO:0051539 4 iron, 4 sulfur cluster binding

	Biological Process
GO:0006120	mitochondrial electron transport, NADH to ubiquinone
GO:0009060	aerobic respiration
GO:0042775	mitochondrial ATP synthesis coupled electron transport
GO:0042776	proton motive force-driven mitochondrial ATP synthesis
GO:1902600	proton transmembrane transport

	Cellular Component
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005829	cytosol
GO:0045271	respiratory chain complex I

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