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Structure of PDB 1af0 Chain A Binding Site BS06

Receptor Information >1af0 Chain A (length=470) Species: 615 (Serratia marcescens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] ATTGYDAVDDLLHYHERGNGIQINGKDSFSNEQAGLFITRENQTWNGYKV FGQPVKLTFSFPDYKFSSTNVAGDTGLSKFSAEQQQQAKLSLQSWADVAN ITFTEVAAGQKANITFGNYSQDRPGHYDYGTQAYAFLPNTIWQGQDLGGQ TWYNVNQSNVKHPATEDYGRQTFTHEIGHALGLSHPGDYNAGEGDPTYND VTYAEDTRQFSLMSYWSETNTGGDNGGHYAAAPLLDDIAAIQHLYGANLS TRTGDTVYGFNSNTGRDFLSTTSNSQKVIFAAWDAGGNDTFDFSGYTANQ RINLNEKSFSDVGGLKGNVSIAAGVTIENAIGGSGNDVIVGNAANNVLKG GAGNDVLFGGGGADELWGGAGKDIFVFSAASDSAPGASDWIRDFQKGIDK IDLSFFDKEANSSSFIHFVDHFSGTAGEALLSYNASSNVTDLSVNIGGHQ APDFLVKIVGQVDVATDFIV

Ligand information Ligand ID CA InChI InChI=1S/Ca/q+2 InChIKey BHPQYMZQTOCNFJ-UHFFFAOYSA-N SMILES Software SMILES CACTVS 3.341 [Ca++] ACDLabs 10.04 OpenEye OEToolkits 1.5.0 [Ca+2] Formula Ca Name CALCIUM ION ChEMBL DrugBank DB14577 ZINC PDB chain 1af0 Chain A Residue 482 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1af0 Kinetic characterization of the serralysins: a divergent catalytic mechanism pertaining to astacin-type metalloproteases. Resolution 1.8 Å Binding residue (original residue number in PDB) G352 A353 G354 D356 G369 A371 D374 Binding residue (residue number reindexed from 1) G351 A352 G353 D355 G368 A370 D373 Annotation score 4

Enzymatic activity Enzyme Commision number 3.4.24.40: serralysin.

Gene Ontology Molecular Function GO:0004222 metalloendopeptidase activity GO:0005509 calcium ion binding GO:0008237 metallopeptidase activity GO:0008270 zinc ion binding GO:0046872 metal ion binding GO:0090729 toxin activity

	Biological Process
GO:0001907	symbiont-mediated killing of host cell
GO:0006508	proteolysis
GO:0035821	modulation of process of another organism

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0031012	extracellular matrix

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