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BioLiP

Structure of PDB 9b6h Chain C Binding Site BS05

Receptor Information
>9b6h Chain C (length=934) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DLVNFIQANFKDAFGDIQFGKYLRLSCDTDSETLYELLTQHWHLKTPNLV
ISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWILTGGTHYGLMKYIGEV
VRDNTISENIVAIGIAAWGMVSNRDTLFSAQYIMLYILDNNHTHLLLVDN
GCHGHPTVEAKLRNQLEKYISERTSQDSNYGGKIPIVCFAQGGGRETLKA
INTSVKSKIPCVVVEGSGQIADVIASLVTSSMVKEKLVRFLPRTVSRLPE
EEIESWIKWLKEILESSHLLTVIKMEEAGDEIVSNAISYALYKAFSTNEQ
DKDNWNGQLKLLLEWNQLDLASDEIFTNDRRWESADLQEVMFTALIKDRP
KFVRLFLENGLNLQKFLTNEVLTELFSTHFSTLVYRNLQIAKNSYNDALL
TFVWKLVANFRRSTRHPLQALFIWAILQNKKELSKVIWEQTKGCTLAALG
ASKLLKTLAKVKNDINAAGESEELANEYETRAVELFTECYSNDEDLAEQL
LVYSCEAWGGSNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNW
KIILCLFIIPLVGCGLVSFRKKKLLWYYVAFFTSPFVVFSWNVVFYIAFL
LLFAYVLLMDFHSVPHTPELILYALVFVLFCDEVRQWYMNGVNYFTDLWN
VMDTLGLFYFIAGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTV
SRNLGPKIIMLQRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWI
FRSVIYEPYLAMFGQVPSDVDSTTYDFSHCTFSGNESKPLCVELDEHNLP
RFPEWITIPLVCIYMLSTNILLVNLLVAMFGYTVGIVQENNDQVWKFQRY
FLVQEYCNRLNIPFPFVVFAYFYMVVKKDNETLAWEGVMKENYLVKINTK
ANDNSEEMRHRFRQLDSKLNDLKSLLKEIANNIK
Ligand information
Ligand IDULO
InChIInChI=1S/C15H33OP/c1-6-7-8-9-10-11-12-13-17(16,14(2)3)15(4)5/h14-15H,6-13H2,1-5H3
InChIKeyDHOTYMJGZIUWRT-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.385CCCCCCCCC[P](=O)(C(C)C)C(C)C
OpenEye OEToolkits 2.0.7CCCCCCCCCP(=O)(C(C)C)C(C)C
ACDLabs 12.01O=P(CCCCCCCCC)(C(C)C)C(C)C
FormulaC15 H33 O P
Namenonyl(oxo)di(propan-2-yl)-lambda~5~-phosphane
ChEMBL
DrugBank
ZINC
PDB chain9b6h Chain C Residue 1301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB9b6h Mechanisms of sensory adaptation and inhibition of the cold and menthol receptor TRPM8.
Resolution2.76 Å
Binding residue
(original residue number in PDB)		N741 Y745 M801 D802 F839 R842 I846 Y1005 F1013
Binding residue
(residue number reindexed from 1)		N592 Y596 M652 D653 F690 R693 I697 Y856 F864
Annotation score1
External links
PDB RCSB:9b6h, PDBe:9b6h, PDBj:9b6h
PDBsum9b6h
PubMed39093967
UniProtQ8R4D5|TRPM8_MOUSE Transient receptor potential cation channel subfamily M member 8 (Gene Name=Trpm8)

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