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Structure of PDB 4k3l Chain B Binding Site BS05

Receptor Information >4k3l Chain B (length=359) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] MKFTVEREHLLKPLQQVSGLPILGNLLLQVADGTLSLTGTDLEMEMVARV ALVQPHEPGATTVPARKFFDICRGLPEGAEIAVQLEGERMLVRSGRSRFS LSTLPAADFPNLDDWQSEVEFTLPQATMKRLIEATQFSMAHQDVRYYLNG MLFETEGEELRTVATDGHRLAVCSMPIGQSLPSHSVIVPRKGVIELMRML DGGDNPLRVQIGSNNIRAHVGDFIFTSKLVDGRFPDYRRVLPKNPDKHLE AGCDLLKQAFARAAILSNEKFRGVRLYVSENQLKITANNPEQEEAEEILD VTYSGAEMEIGFNVSYVLDVLNALKCENVRMMLTDSVSSVQIEDAASQSA AYVVMPMRL

Ligand information Ligand ID CA InChI InChI=1S/Ca/q+2 InChIKey BHPQYMZQTOCNFJ-UHFFFAOYSA-N SMILES Software SMILES CACTVS 3.341 [Ca++] ACDLabs 10.04 OpenEye OEToolkits 1.5.0 [Ca+2] Formula Ca Name CALCIUM ION ChEMBL DrugBank DB14577 ZINC PDB chain 4k3l Chain B Residue 406 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 4k3l Structural and Thermodynamic Dissection of Linear Motif Recognition by the E. coli Sliding Clamp Resolution 1.5 Å Binding residue (original residue number in PDB) G46 T47 E202 Binding residue (residue number reindexed from 1) G39 T40 E195 Annotation score 1

Enzymatic activity Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology Molecular Function GO:0003677 DNA binding GO:0003887 DNA-directed DNA polymerase activity GO:0005515 protein binding GO:0008408 3'-5' exonuclease activity GO:0042802 identical protein binding GO:0042803 protein homodimerization activity

	Biological Process
GO:0006260	DNA replication
GO:0006261	DNA-templated DNA replication
GO:0006271	DNA strand elongation involved in DNA replication
GO:0006974	DNA damage response
GO:0030174	regulation of DNA-templated DNA replication initiation
GO:0032297	negative regulation of DNA-templated DNA replication initiation
GO:0042276	error-prone translesion synthesis
GO:0044787	bacterial-type DNA replication

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0009360	DNA polymerase III complex
GO:0030894	replisome
GO:1990078	replication inhibiting complex
GO:1990085	Hda-beta clamp complex

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