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Structure of PDB 1c8t Chain B Binding Site BS05

Receptor Information >1c8t Chain B (length=167) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] FPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRL YEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQ WTKDTTGTNLFLVAAHQIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLS QDDINGIQSLYGPPPDP

Ligand information Ligand ID CA InChI InChI=1S/Ca/q+2 InChIKey BHPQYMZQTOCNFJ-UHFFFAOYSA-N SMILES Software SMILES CACTVS 3.341 [Ca++] ACDLabs 10.04 OpenEye OEToolkits 1.5.0 [Ca+2] Formula Ca Name CALCIUM ION ChEMBL DrugBank DB14577 ZINC PDB chain 1c8t Chain B Residue 264 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1c8t Expression, characterization and structure determination of an active site mutant (Glu202-Gln) of mini-stromelysin-1. Resolution 2.6 Å Binding residue (original residue number in PDB) D107 D182 E184 Q185 Binding residue (residue number reindexed from 1) D22 D97 E99 Q100 Annotation score 4

Enzymatic activity Catalytic site (original residue number in PDB) H201 Q202 H205 H211 Catalytic site (residue number reindexed from 1) H116 Q117 H120 H126 Enzyme Commision number 3.4.24.17: stromelysin 1.

Gene Ontology Molecular Function GO:0004222 metalloendopeptidase activity GO:0008237 metallopeptidase activity GO:0008270 zinc ion binding

	Biological Process
GO:0006508	proteolysis

	Cellular Component
GO:0031012	extracellular matrix

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