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●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

Structure of PDB 5mc0 Chain B Binding Site BS04

Receptor Information >5mc0 Chain B (length=480) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] GPSFWLGNETLKVPLALFALNRQRLCERLRKNPAVQAGSIVVLQGGEETQ RYCTDTGVLFRQESFFHWAFGVTEPGCYGVIDVDTGKSTLFVPRLPASHA TWMGKIHSKEHFKEKYAVDDVQYVDEIASVLTSQKPSVLLTLRGVNTDSG SVCREASFDGISKFEVNNTILHPEIVECRVFKTDMELEVLRYTNKISSEA HREVMKAVKVGMKEYELESLFEHYCSRGGMRHSSYTCICGSGENSAVLHY GHAGAPNDRTIQNGDMCLFDMGGEYYCFASDITCSFPANGKFTADQKAVY EAVLRSSRAVMGAMKPGVWWPDMHRLADRIHLEELAHMGILSGSVDAMVQ AHLGAVFMPHGLGHFLGIDVHDVGGYPEGVERIDEPGLRSLRTARHLQPG MVLTVEPGIYFIDHLLDEALADPARASFLNREVLQRFRGFGGVRIEEDVV VTDSGIELLTCVPRTVEEIEACMAGCDKAF

Ligand information Ligand ID PRO InChI InChI=1S/C5H9NO2/c7-5(8)4-2-1-3-6-4/h4,6H,1-3H2,(H,7,8)/t4-/m0/s1 InChIKey ONIBWKKTOPOVIA-BYPYZUCNSA-N SMILES Software SMILES OpenEye OEToolkits 1.5.0 C1C[C@H](NC1)C(=O)O CACTVS 3.341 OC(=O)[C@@H]1CCCN1 CACTVS 3.341 OC(=O)[CH]1CCCN1 OpenEye OEToolkits 1.5.0 C1CC(NC1)C(=O)O ACDLabs 10.04 O=C(O)C1NCCC1 Formula C5 H9 N O2 Name PROLINE ChEMBL CHEMBL54922 DrugBank DB00172 ZINC ZINC000000895360 PDB chain 5mc0 Chain B Residue 504 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 5mc0 Structural basis for prolidase deficiency disease mechanisms. Resolution 1.56 Å Binding residue (original residue number in PDB) H254 H365 H376 R397 E411 R449 Binding residue (residue number reindexed from 1) H249 H360 H371 R392 E406 R444 Annotation score 1

Enzymatic activity Enzyme Commision number 3.4.13.9: Xaa-Pro dipeptidase.

Gene Ontology Molecular Function GO:0004181 metallocarboxypeptidase activity GO:0005515 protein binding GO:0008233 peptidase activity GO:0008237 metallopeptidase activity GO:0016805 dipeptidase activity GO:0030145 manganese ion binding GO:0046872 metal ion binding GO:0070006 metalloaminopeptidase activity GO:0102009 proline dipeptidase activity

	Biological Process
GO:0006508	proteolysis
GO:0006520	amino acid metabolic process
GO:0030574	collagen catabolic process
GO:0043069	negative regulation of programmed cell death

	Cellular Component
GO:0070062	extracellular exosome

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