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BioLiP

Structure of PDB 7sr6 Chain F Binding Site BS03

Receptor Information
>7sr6 Chain F (length=566) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KPIPLTWKTEKPVWVNQWPLPKQKLEALHLLANEQLEKGHIEPSFSPWNS
PVFVIQKKSGKWRMLTDLRAVNALIQPMGPLQPGLPSPAMIPKDWPLIII
DLKDCFFTIPLAEQDCEKFAFTIPAINNKEPATRFQWKVLPQGMLNSPTI
CQTFVGRALQPVREKFSDCYIIHYIDDILCAAETKDKLIDCYTFLQAEVA
NAGLAIASDKIQTSTPFHYLGMQIENRKIKPQKIEIRKDTLKTLNDFQKL
LGDINWIRPTLGIPTYAMSNLFSILRGDSDLNSKRILTPEATKEIKLVEE
KIQSAQINRIGPLAPLQLLIFATAHSPTGIIIQNTDLVEWSFLPHSTVKT
FTLYLDQIATLIGQTRLRITKLCGNDPDKIVVPLTKEQVRQAFINSGAWQ
IGLANFVGIIDNHYPKTKIFQFLKLTTWILPKITRCEPLENALTVFTDGS
SNGKAAYTGPKERVIKTPYQSAQRAELVAVITVLQDFDQPINIISDSAYV
VQATRDVETALIKYSMDDQLNQLFNLLQQTVRKRNFPFYITHIRAHTNLP
GPLTKANEQADLLVSS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB7sr6 Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K-specific inhibition.
Resolution2.62 Å
Binding residue
(original residue number in PDB)		L105 Y194 D196 L240 G241 K253 R257 Q268 K269 G272 W276 V368 K369 T370 Q493 Y519
Binding residue
(residue number reindexed from 1)		L85 Y174 D176 L220 G221 K233 R237 Q248 K249 G252 W256 V348 K349 T350 Q473 Y499
Enzymatic activity
Enzyme Commision number 2.7.7.49: RNA-directed DNA polymerase.
3.1.26.4: ribonuclease H.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003964 RNA-directed DNA polymerase activity
GO:0004523 RNA-DNA hybrid ribonuclease activity
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7sr6, PDBe:7sr6, PDBj:7sr6
PDBsum7sr6
PubMed35771941
UniProtQ9UQG0|POK11_HUMAN Endogenous retrovirus group K member 11 Pol protein (Gene Name=ERVK-11)

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