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Structure of PDB 7z11 Chain D Binding Site BS03

Receptor Information >7z11 Chain D (length=734) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] KFKLPAEFITRPHPSKDHGKETCTAYIHPNVLSSLEINPGSFCTVGKIGE NGILVIARAGDEEVHPVNVITLSTTIRSVGNLILGDRLELKKAQVQPPYA TKVTVGSLQGYNILECMEEKVIQKLLDDSGVIMPGMIFQNLKTKAGDESI DVVITDASDDNLFYLSPPFIFRKGSTHITFSKETQANRKYNLPEPLSYAA VGGLDKEIESLKSAIEIPLHQPTLFSSFGVSPPRGILLHGPPGTGKTMLL RVVANTSNAHVLTINGPSIVSKYLGETEAALRDIFNEARKYQPSIIFIDE IDSIAPNRANDDSGEVESRVVATLLTLMDGMGAAGKVVVIAATNRPNSVD PALRRPGRFDQEVEIGIPDVDARFDILTKQFSRMSSDRHVLDSEAIKYIA SKTHGYVGADLTALCRESVMKTIQRGLGTDANIDKFSLKVTLKDVESAMV DIRPSAMREIFLEMPKVYWSDIGGQEELKTKMKEMIQLPLEASETFARLG ISAPKGVLLYGPPGCSKTLTAKALATESGINFLAVKGPEIFNKYVGESER AIREIFRKARSAAPSIIFFDEIDALSPDRDGSSTSAANHVLTSLLNEIDG VEELKGVVIVAATNRPDEIDAALLRPGRLDRHIYVGPPDVNARLEILKKC TKKFNTEESGVDLHELADRTEGYSGAEVVLLCQEAGLAAIMEDLDVAKVE LRHFEKAFKGIARGITPEMLSYYEEFALRSGSSS

Ligand information Ligand ID AGS InChI InChI=1S/C10H16N5O12P3S/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-28(18,19)26-29(20,21)27-30(22,23)31/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,20,21)(H2,11,12,13)(H2,22,23,31)/t4-,6-,7-,10-/m1/s1 InChIKey NLTUCYMLOPLUHL-KQYNXXCUSA-N SMILES Software SMILES OpenEye OEToolkits 1.7.6 c1nc(c2c(n1)n(cn2)C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=S)(O)O)O)O)N CACTVS 3.370 Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=S)[C@@H](O)[C@H]3O CACTVS 3.370 Nc1ncnc2n(cnc12)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=S)[CH](O)[CH]3O OpenEye OEToolkits 1.7.6 c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(O)OP(=O)(O)OP(=S)(O)O)O)O)N ACDLabs 12.01 O=P(O)(OP(=S)(O)O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O Formula C10 H16 N5 O12 P3 S Name PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER; ATP-GAMMA-S; ADENOSINE 5'-(3-THIOTRIPHOSPHATE); ADENOSINE 5'-(GAMMA-THIOTRIPHOSPHATE); ADENOSINE-5'-DIPHOSPHATE MONOTHIOPHOSPHATE ChEMBL CHEMBL131890 DrugBank DB02930 ZINC ZINC000008295128 PDB chain 7z11 Chain D Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 7z11 Visualizing maturation factor extraction from the nascent ribosome by the AAA-ATPase Drg1. Resolution 3.2 Å Binding residue (original residue number in PDB) T290 G291 K292 T293 D345 T458 Binding residue (residue number reindexed from 1) T244 G245 K246 T247 D299 T412 Annotation score 4

Enzymatic activity Enzyme Commision number 3.6.4.10: non-chaperonin molecular chaperone ATPase.

Gene Ontology Molecular Function GO:0005515 protein binding GO:0005524 ATP binding GO:0016787 hydrolase activity GO:0016887 ATP hydrolysis activity

	Biological Process
GO:0009410	response to xenobiotic stimulus
GO:0034214	protein hexamerization
GO:0042254	ribosome biogenesis
GO:0042273	ribosomal large subunit biogenesis

	Cellular Component
GO:0005737	cytoplasm
GO:0030687	preribosome, large subunit precursor

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