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BioLiP

Structure of PDB 8gio Chain C Binding Site BS03

Receptor Information
>8gio Chain C (length=340) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNT
GSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFPLSHFVLS
ATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVDI
ILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKQGETWRLS
FSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQELD
AFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTEKLD
HYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB8gio Structure of Ternary Complex of mouse cGAS with dsDNA and Bound ATP: with 10mM Mg2+ and 0.1mM Mn2+
Resolution2.67 Å
Binding residue
(original residue number in PDB)		R158 L159 K160 R161 K184 K395
Binding residue
(residue number reindexed from 1)		R11 L12 K13 R14 K37 K229
Enzymatic activity
Enzyme Commision number 2.7.7.86: cyclic GMP-AMP synthase.
External links
PDB RCSB:8gio, PDBe:8gio, PDBj:8gio
PDBsum8gio
PubMed38740774
UniProtQ8C6L5|CGAS_MOUSE Cyclic GMP-AMP synthase (Gene Name=Cgas)

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