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Structure of PDB 6zy6 Chain A Binding Site BS03

Receptor Information >6zy6 Chain A (length=760) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] NRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYG VFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLR YGKIMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSK NKQEMAFYSLPEFEEWKSSTPNHKKWKVKYYKGLGTSTSKEAKEYFADMK RHRIQFKYSGPEDDAAISLAFSKKQIDDRKEWLTNFMEDRRQRKLLGLPE DYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRKVLFT CFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLN LLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDD NQRVEPEWYIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDG EEPLPMLPSYKNFKGTIEELAPNQYVISGEVAILNSTTIEISELPVRTWT QTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKFVVKMTEEKLAEAER VGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLKYYGL RKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGY DSDPVKAWKEAQQKVSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQEL DTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAKGKKT QMAEVLPSPR

Ligand information >6zy6 Chain C (length=13) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] gaggatgacgatg

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 6zy6 Structural basis for allosteric regulation of Human Topoisomerase II alpha. Resolution 4.1 Å Binding residue (original residue number in PDB) K489 S497 D545 R713 K723 H759 S763 N770 E854 I856 R929 Binding residue (residue number reindexed from 1) K57 S65 D113 R281 K291 H327 S331 N338 E422 I424 R497

Enzymatic activity Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

Gene Ontology Molecular Function GO:0000287 magnesium ion binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0003723 RNA binding GO:0003916 DNA topoisomerase activity GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity GO:0005080 protein kinase C binding GO:0005515 protein binding GO:0005524 ATP binding GO:0008094 ATP-dependent activity, acting on DNA GO:0008301 DNA binding, bending GO:0042803 protein homodimerization activity GO:0043130 ubiquitin binding GO:0046872 metal ion binding GO:0046982 protein heterodimerization activity

	Biological Process
GO:0000712	resolution of meiotic recombination intermediates
GO:0000819	sister chromatid segregation
GO:0002244	hematopoietic progenitor cell differentiation
GO:0006259	DNA metabolic process
GO:0006265	DNA topological change
GO:0006266	DNA ligation
GO:0006974	DNA damage response
GO:0007059	chromosome segregation
GO:0007143	female meiotic nuclear division
GO:0030261	chromosome condensation
GO:0030263	apoptotic chromosome condensation
GO:0040016	embryonic cleavage
GO:0042752	regulation of circadian rhythm
GO:0043065	positive regulation of apoptotic process
GO:0045870	positive regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO:0045944	positive regulation of transcription by RNA polymerase II
GO:0048511	rhythmic process
GO:0060255	regulation of macromolecule metabolic process
GO:1905463	negative regulation of DNA duplex unwinding

	Cellular Component
GO:0000228	nuclear chromosome
GO:0000775	chromosome, centromeric region
GO:0000793	condensed chromosome
GO:0001673	male germ cell nucleus
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005814	centriole
GO:0009330	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex
GO:0032991	protein-containing complex
GO:1990904	ribonucleoprotein complex

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