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Structure of PDB 2x0r Chain A Binding Site BS03

Receptor Information >2x0r Chain A (length=303) Species: 2238 (Haloarcula marismortui) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] TKVSVVGAAGTVGAAAGYNIALRDIADEVVFVDIPDKEDDTVGQAADTNH GIAYDSNTRVRQGGYEDTAGSDVVVITAGIPRQPGQTRIDLAGDNAPIME DIQSSLDEHNDDYISLTTSNPVDLLNRHLYEAGDRSREQVIGFGGRLDSA RFRYVLSEEFDAPVQNVEGTILGEHGDAQVPVFSKVSVDGTDPEFSGDEK EQLLGDLQESAMDVIERKGATEWGPARGVAHMVEAILHDTGEVLPASVKL EGEFGHEDTAFGVPVSLGSNGVEEIVEWDLDDYEQDLMADAAEKLSDQYD KIS

Ligand information Ligand ID CL InChI InChI=1S/ClH/h1H/p-1 InChIKey VEXZGXHMUGYJMC-UHFFFAOYSA-M SMILES Software SMILES ACDLabs 10.04 CACTVS 3.341 OpenEye OEToolkits 1.5.0 [Cl-] Formula Cl Name CHLORIDE ION ChEMBL DrugBank DB14547 ZINC PDB chain 2x0r Chain A Residue 1004 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 2x0r The Oligomeric States of Haloarcula Marismortui Malate Dehydrogenase are Modulated by Solvent Components as Shown by Crystallographic and Biochemical Studies Resolution 2.915 Å Binding residue (original residue number in PDB) R252 E259 Binding residue (residue number reindexed from 1) R227 E234 Annotation score 1

Enzymatic activity Catalytic site (original residue number in PDB) R109 D168 R171 H195 Catalytic site (residue number reindexed from 1) R88 D148 R151 H175 Enzyme Commision number 1.1.1.37: malate dehydrogenase.

Gene Ontology Molecular Function GO:0003824 catalytic activity GO:0004459 L-lactate dehydrogenase activity GO:0016491 oxidoreductase activity GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0030060 L-malate dehydrogenase (NAD+) activity

	Biological Process
GO:0006089	lactate metabolic process
GO:0006090	pyruvate metabolic process
GO:0006099	tricarboxylic acid cycle
GO:0019752	carboxylic acid metabolic process

	Cellular Component
GO:0005737	cytoplasm

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