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Structure of PDB 1v2x Chain A Binding Site BS03

Receptor Information
>1v2x Chain A (length=191) Species: 274 (Thermus thermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRERTEARRRRIEEVLRRRQPDLTVLLENVHKPHNLSAILRTCDAVGVLE
AHAVNPTGGVPTFNETSGGSHKWVYLRVHPDLHEAFRFLKERGFTVYATA
LREDARDFREVDYTKPTAVLFGAEKWGVSEEALALADGAIKIPMLGMVQS
LNVSVAAAVILFEAQRQRLKAGLYDRPRLDPELYQKVLADW
Ligand information
Ligand IDSAM
InChIInChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/t7-,8+,10+,11+,14+,27-/m0/s1
InChIKeyMEFKEPWMEQBLKI-FCKMPRQPSA-N
SMILES
SoftwareSMILES
CACTVS 3.341C[S@@+](CC[C@H](N)C([O-])=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
OpenEye OEToolkits 1.5.0C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)n2cnc3c2ncnc3N)O)O
CACTVS 3.341C[S+](CC[CH](N)C([O-])=O)C[CH]1O[CH]([CH](O)[CH]1O)n2cnc3c(N)ncnc23
OpenEye OEToolkits 1.5.0C[S@@+](CC[C@@H](C(=O)[O-])N)C[C@@H]1[C@H]([C@H]([C@@H](O1)n2cnc3c2ncnc3N)O)O
ACDLabs 10.04[O-]C(=O)C(N)CC[S+](C)CC3OC(n2cnc1c(ncnc12)N)C(O)C3O
FormulaC15 H22 N6 O5 S
NameS-ADENOSYLMETHIONINE
ChEMBLCHEMBL1235831
DrugBank
ZINC
PDB chain1v2x Chain A Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB1v2x Deep Knot Structure for Construction of Active Site and Cofactor Binding Site of tRNA Modification Enzyme
Resolution1.5 Å
Binding residue
(original residue number in PDB)		T99 F121 G122 E124 K125 W126 G127 K141 I142 M144 L151 V153 A156
Binding residue
(residue number reindexed from 1)		T99 F121 G122 E124 K125 W126 G127 K141 I142 M144 L151 V153 A156
Annotation score5
Enzymatic activity
Enzyme Commision number 2.1.1.34: tRNA (guanosine(18)-2'-O)-methyltransferase.
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0008168 methyltransferase activity
GO:0008173 RNA methyltransferase activity
GO:0141100 tRNA (guanine(18)-2'-O)-methyltransferase activity
Biological Process
GO:0002938 tRNA guanine ribose methylation
GO:0006396 RNA processing
GO:0008033 tRNA processing
GO:0030488 tRNA methylation
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1v2x, PDBe:1v2x, PDBj:1v2x
PDBsum1v2x
PubMed15062082
UniProtQ5SM16|TRMH_THET8 tRNA (guanosine(18)-2'-O)-methyltransferase (Gene Name=trmH)

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