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Structure of PDB 8pk0 Chain x Binding Site BS02

Receptor Information >8pk0 Chain x (length=338) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] TEPKFPAVRLALQNFDMTYSVQFGDLWPSIRVSLLSEQKYGALVNNFAAW DHVSAKLEQLSAKDFVNEAISHWELQSWACSPNLRCFTFDRGDISRFPPA RPGSLGVMEYYLMDAASLLPVLALGLQPGDIVLDLCAAPGGKTLALLQTG CCRNLAANDLSPSRIARLQKILHSYVPEEIRDGNQVRVTSWDGRKWGELE GDTYDRVLVDVPCTTDRHSLHEEENNIFKRSRKKERQILPVLQVQLLAAG LLATKPGGHVVYSTCSLSHLQNEYVVQGAIELLANQYSIQVQVEDLTHFR RVFMDTFCFFSSCQVGELVIPNLMANFGPMYFCKMRRL

Ligand information Ligand ID SAM InChI InChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/t7-,8+,10+,11+,14+,27-/m0/s1 InChIKey MEFKEPWMEQBLKI-FCKMPRQPSA-N SMILES Software SMILES CACTVS 3.341 C[S@@+](CC[C@H](N)C([O-])=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23 OpenEye OEToolkits 1.5.0 C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)n2cnc3c2ncnc3N)O)O CACTVS 3.341 C[S+](CC[CH](N)C([O-])=O)C[CH]1O[CH]([CH](O)[CH]1O)n2cnc3c(N)ncnc23 OpenEye OEToolkits 1.5.0 C[S@@+](CC[C@@H](C(=O)[O-])N)C[C@@H]1[C@H]([C@H]([C@@H](O1)n2cnc3c2ncnc3N)O)O ACDLabs 10.04 [O-]C(=O)C(N)CC[S+](C)CC3OC(n2cnc1c(ncnc12)N)C(O)C3O Formula C15 H22 N6 O5 S Name S-ADENOSYLMETHIONINE ChEMBL CHEMBL1235831 DrugBank ZINC PDB chain 8pk0 Chain x Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 8pk0 Structural insights into the role of GTPBP10 in the RNA maturation of the mitoribosome. Resolution 3.03 Å Binding residue (original residue number in PDB) C181 A182 A183 K187 D204 L205 R209 G238 D255 P257 L291 Binding residue (residue number reindexed from 1) C136 A137 A138 K142 D159 L160 R164 G193 D210 P212 L246 Annotation score 5

Enzymatic activity Enzyme Commision number 2.1.1.-

Gene Ontology Molecular Function GO:0005515 protein binding GO:0008168 methyltransferase activity GO:0008173 RNA methyltransferase activity GO:0008649 rRNA methyltransferase activity GO:0008757 S-adenosylmethionine-dependent methyltransferase activity GO:0009383 rRNA (cytosine-C5-)-methyltransferase activity GO:0016428 tRNA (cytidine-5-)-methyltransferase activity GO:0019843 rRNA binding

	Biological Process
GO:0001510	RNA methylation
GO:0006364	rRNA processing
GO:0031167	rRNA methylation
GO:0032259	methylation
GO:0042254	ribosome biogenesis

	Cellular Component
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0005762	mitochondrial large ribosomal subunit

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