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Structure of PDB 8wrb Chain R Binding Site BS02

Receptor Information >8wrb Chain R (length=281) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] EKLLSTVLTTSYSVIFIVGLVGNIIALYVFLGIHRKRNSIQIYLLNVAIA DLLLIFCLPFRIMYHINQNKWTLGVILCKVVGTLFYMNMYISIILLGFIS LDRYIKINTTKQSIYVCCIVWMLALGGFLTMIILTLKKGGHNSTMCFHYR DKHNAKGEAIFNFILVVMFWLIFLLIILSYIKIGKNLLRISKRRSKFPNS GKYATTARNSFIVLIIFTICFVPYHAFRFIYISSQLNVSSCYWKEIVHKT NEIMLVLSSFNSCLDPVMYFLMSSNIRKIMC

Ligand information Ligand ID UBL InChI InChI=1S/C21H41O7P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(23)27-18-20(22)19-28-29(24,25)26/h9-10,20,22H,2-8,11-19H2,1H3,(H2,24,25,26)/b10-9-/t20-/m1/s1 InChIKey WRGQSWVCFNIUNZ-GDCKJWNLSA-N SMILES Software SMILES OpenEye OEToolkits 2.0.7 CCCCCCCCC=CCCCCCCCC(=O)OCC(COP(=O)(O)O)O OpenEye OEToolkits 2.0.7 CCCCCCCC/C=C\CCCCCCCC(=O)OC[C@H](COP(=O)(O)O)O CACTVS 3.385 CCCCCCCCC=CCCCCCCCC(=O)OC[CH](O)CO[P](O)(O)=O CACTVS 3.385 CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)CO[P](O)(O)=O Formula C21 H41 O7 P Name [(2R)-2-oxidanyl-3-phosphonooxy-propyl] (Z)-octadec-9-enoate ChEMBL CHEMBL117021 DrugBank ZINC ZINC000008860530 PDB chain 8wrb Chain R Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 8wrb Structural basis for ligand recognition and signaling of the lysophosphatidylserine receptors GPR34 and GPR174 Resolution 2.91 Å Binding residue (original residue number in PDB) A182 M189 F205 R208 N220 L223 M226 Binding residue (residue number reindexed from 1) A124 M131 F147 R150 N162 L165 M168 Annotation score 1

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0004930 G protein-coupled receptor activity GO:0045028 G protein-coupled purinergic nucleotide receptor activity

	Biological Process
GO:0007186	G protein-coupled receptor signaling pathway
GO:0035589	G protein-coupled purinergic nucleotide receptor signaling pathway

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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