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Structure of PDB 7wnh Chain D Binding Site BS02

Receptor Information >7wnh Chain D (length=316) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] CAVCGDNAACQHYGVRTCEGCKGFFKRTVQKNAKYVCLANKNCPVDKRRR NRCQYCRFQKCLAVGMVKEVVRTDSLKGRRGRLPPVSLISALVRAHVDSN PAMTSLDYSRFQANPSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADL PKADQDLLFESAFLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFG EWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNK IVNCLKDHVTFNNGGLNRPNYLSKLLGKLPELRTLCTQGLQRIFYLKLED LVPPPAIIDKLFLDTL

Ligand information >7wnh Chain N (length=16) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] ccgaaaaggtcatgcg

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 7wnh Integrative analysis reveals structural basis for transcription activation of Nurr1 and Nurr1-RXR alpha heterodimer. Resolution 3.1 Å Binding residue (original residue number in PDB) C272 Q273 H274 Y275 V332 R334 G340 R342 G343 R344 Binding residue (residue number reindexed from 1) C10 Q11 H12 Y13 V70 R72 G78 R80 G81 R82

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0003677 DNA binding GO:0003700 DNA-binding transcription factor activity GO:0004879 nuclear receptor activity GO:0008270 zinc ion binding GO:0043565 sequence-specific DNA binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription

	Cellular Component
GO:0005634	nucleus

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