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Structure of PDB 5tf6 Chain C Binding Site BS02

Receptor Information
>5tf6 Chain C (length=366) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLTRNRELTTVLVKNLPKSYNQNKVYKYFKHCGPIIHVDVADSLKKNFRF
ARIEFARYDGALAAITKTHKVVGQNEIIVSHLTECTLWMTNFPPSYTQRN
IRDLLQDINVVALSIRLPSLRFNTSRRFAYIDVTSKEDARYCVEKLNGLK
IEGYTLVTKVSNPLEKSKRTDSATLEGREIMIRNLSTELLDENLLRESFE
GFGSIEKINIPAGQKEHSFNNCCAFMVFENKDSAERALQMNRSLLGNREI
SVSLADKKPFLERNEVKRLLASRNSKELETLICLFPLSDKVSPSLICQFL
QEEIHINEKDIRKILLVSDFNGAIIIFRDSKFAAKMLMILNGSQFQGKVI
RSGTINDMKRYYNNQQ
Ligand information
>5tf6 Chain D (length=52) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ggucaauuugaaacaauacagagaugaucagcagccguuuuacaaagaga
cc
<<.<..<<<<...................<<<....>>>...>>>>..>.
>>
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5tf6 Structure and conformational plasticity of the U6 small nuclear ribonucleoprotein core.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		M33 T35 R36 R38 W120 T122 N123 R148 P150 S151 F154 R158 R159 F160 Y162 S193 N194 P195 K198 R201 T202 D203 T206 E211 M213 R215 N216 K239 N241 P243 Q246 F251 N252 N253 C255 F257 S283 D288 K289 K290 P291 F292 R295 K299
Binding residue
(residue number reindexed from 1)		M1 T3 R4 R6 W88 T90 N91 R116 P118 S119 F122 R126 R127 F128 Y130 S161 N162 P163 K166 R169 T170 D171 T174 E179 M181 R183 N184 K207 N209 P211 Q214 F219 N220 N221 C223 F225 S251 D256 K257 K258 P259 F260 R263 K267
Binding affinityPDBbind-CN: Kd=2.9nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding

View graph for
Molecular Function
External links
PDB RCSB:5tf6, PDBe:5tf6, PDBj:5tf6
PDBsum5tf6
PubMed28045380
UniProtP49960|PRP24_YEAST U4/U6 snRNA-associated-splicing factor PRP24 (Gene Name=PRP24)

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