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Structure of PDB 5huw Chain C Binding Site BS02

Receptor Information >5huw Chain C (length=423) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] NWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKF VSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASP HAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLSTLACG YLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWA ISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGT DEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVV NHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHCGIIEP LMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIE ALQRHENESVYKASLNLIEKYFS

Ligand information >5huw Chain B (length=6) Species: 10298 (Human alphaherpesvirus 1) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] PPKKRA

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 5huw Divergent Evolution of Nuclear Localization Signal Sequences in Herpesvirus Terminase Subunits. Resolution 1.95 Å Binding residue (original residue number in PDB) G281 V321 T322 G323 W357 N361 A364 W399 S406 G407 Binding residue (residue number reindexed from 1) G207 V247 T248 G249 W283 N287 A290 W325 S332 G333

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0005515 protein binding GO:0061608 nuclear import signal receptor activity GO:0140297 DNA-binding transcription factor binding

	Biological Process
GO:0006606	protein import into nucleus
GO:0015031	protein transport
GO:0075506	entry of viral genome into host nucleus through nuclear pore complex via importin
GO:0099527	postsynapse to nucleus signaling pathway
GO:1903902	positive regulation of viral life cycle

	Cellular Component
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0010494	cytoplasmic stress granule
GO:0014069	postsynaptic density
GO:0042564	NLS-dependent protein nuclear import complex
GO:0043657	host cell
GO:0098978	glutamatergic synapse

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