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BioLiP

Structure of PDB 5b4w Chain C Binding Site BS02

Receptor Information
>5b4w Chain C (length=442) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TAFTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLD
SRDCLPPVMPDECPQAQPTNNPNQLLLVSPGALVVCGSVHQGVCEQRRLG
QLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQAGEPLLFVGRGYTSRGI
PPITTRALWPPDPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFL
FLRRDLQAQSRAFRAYVSRVCLRDQHYYSYVELPLACEGGRYGLIQAAAV
ATSREVAHGEVLFAAFSSAAPRPPSAAAASALCAFPLDEVDRLANRTRDA
CYTREGRAEDGTEVAYIEYDVNSDCAQLPVDTLDAYPCGSDHTPSPMASR
VPLEATPILEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGSDG
HPYSTQSIQQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVAS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5b4w Allosteric Inhibition of a Semaphorin 4D Receptor Plexin B1 by a High-Affinity Macrocyclic Peptide
Resolution2.6 Å
Binding residue
(original residue number in PDB)		R245 G270 R272 T351 E352 P391
Binding residue
(residue number reindexed from 1)		R214 G239 R241 T312 E313 P352
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0017154 semaphorin receptor activity
Biological Process
GO:0071526 semaphorin-plexin signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5b4w, PDBe:5b4w, PDBj:5b4w
PDBsum5b4w
PubMed27984026
UniProtO43157|PLXB1_HUMAN Plexin-B1 (Gene Name=PLXNB1)

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