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●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

Structure of PDB 8bdc Chain B Binding Site BS02

Receptor Information >8bdc Chain B (length=963) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] LVNFIQANFKKRECVFFTKDSKATENVCKCGYAQSQHMEGTQINQSEKWN YKKHTKEFPTDAFGDIQFETLGKKGKYIRLSCDTDAEILYELLTQHWHLK TPNLVISVTGGAKNFALKPRMRKIFSRLIYIAQSKGAWILTGGTHYGLMK YIGEVVRDNTISRSSEENIVAIGIAAWGMVSNRDTLIRNYFLAQYLMDDF TRDPLYILDNNHTHLLLVDNGCHGHPTVEAKLRNQLEKYISERTIQDSNY GGKIPIVCFAQGGGKETLKAINTSIKNKIPCVVVEGSGQIADVIASLVEV EDALTSSAVKEKLVRFLPRTVSRLPEEETESWIKWLKEILECSHLLTVIK MEEAGDEIVSNAISYALYKAFSTSEQDKDNWNGQLKLLLEWNQLDLANDE IFTNDRRWESADLQEVMFTALIKDRPKFVRLFLENGLNLRKFLTHDVLTE LFSNHFSTLVYRNLQIAKNSYNDALLTFVWKLVANFRRTRHPLQALFIWA ILQNKKELSKVIWEQTRGCTLAALGASKLLKTLAKVKNDINAAGESEELA NEYETRAVELFTECYSSDEDLAEQLLVYSCEAWGGSNCLELAVEATDQHF IAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIPLVGCGFVSFRKKPKL LWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDFHSVPHPPELVLYS LVFVLFCDEVRQWYVNGVNYFTDLWNVMDTLGLFYFIAGIVFRLHSSNKS SLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIMLQRMLIDVFFFLFL FAVWMVAFGVARQGILRQRWRWIFRSVIYEPYLAMFGPEWITIPLVCIYM LSTNILLVNLLVAMFGYTVGNDQVWKFQRYFLVQEYCSRLNIPFPFIVFA YFYMVVKKCFKDNETLAWEGVMKENYLVKINTKANEMRHRFRQLDTKLND LKGLLKEIANKIK

Ligand information Ligand ID Y01 InChI InChI=1S/C31H50O4/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33)/t21-,23+,24+,25-,26+,27+,30+,31-/m1/s1 InChIKey WLNARFZDISHUGS-MIXBDBMTSA-N SMILES Software SMILES CACTVS 3.352 CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@H](CC[C@]4(C)[C@H]3CC[C@]12C)OC(=O)CCC(O)=O OpenEye OEToolkits 1.6.1 CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)CCC(=O)O)C)C OpenEye OEToolkits 1.6.1 CC(C)CCC[C@@H](C)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)OC(=O)CCC(=O)O)C)C CACTVS 3.352 CC(C)CCC[CH](C)[CH]1CC[CH]2[CH]3CC=C4C[CH](CC[C]4(C)[CH]3CC[C]12C)OC(=O)CCC(O)=O Formula C31 H50 O4 Name CHOLESTEROL HEMISUCCINATE ChEMBL DrugBank ZINC ZINC000058638837 PDB chain 8bdc Chain B Residue 1203 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 8bdc Structure of human TRPM8 channel. Resolution 2.65 Å Binding residue (original residue number in PDB) W693 F700 Binding residue (residue number reindexed from 1) W625 F632 Annotation score 1

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0005216 monoatomic ion channel activity GO:0005262 calcium channel activity GO:0005515 protein binding GO:0042802 identical protein binding GO:0046872 metal ion binding GO:0099604 ligand-gated calcium channel activity

	Biological Process
GO:0006811	monoatomic ion transport
GO:0006816	calcium ion transport
GO:0006874	intracellular calcium ion homeostasis
GO:0009266	response to temperature stimulus
GO:0009409	response to cold
GO:0019722	calcium-mediated signaling
GO:0034220	monoatomic ion transmembrane transport
GO:0050955	thermoception
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0120162	positive regulation of cold-induced thermogenesis

	Cellular Component
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0044853	plasma membrane raft
GO:0045121	membrane raft

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View graph for Biological Process

View graph for Cellular Component