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Structure of PDB 8ag6 Chain B Binding Site BS02

Receptor Information >8ag6 Chain B (length=975) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] SSRPTVWYHETLEWLKEEKRRDEHRRRPDHPDFDASTLYVPEDFLNSCTP GMRKWWQIKSQNFDLVICYKVGKFYELYHMDALIGVSELGLVFMKGNWAH SGFPEIAFGRYSDSLVQKGYKVARVEQTETPEMMEARCRKMAHISKYDRV VRREICRIITKGTQTYSVLEGDPSENYSKYLLSLKEKEEDSSGHTRAYGV CFVDTSLGKFFIGQFSDDRHCSRFRTLVAHYPPVQVLFEKGNLSKETKTI LKSSLSCSLQEGLIPGSQFWDASKTLRTLLEEEYFREKLSDGIGVMLPQV LKGMTSESDSIGLTPGEKSELALSALGGCVFYLKKCLIDQELLSMANFEE YIPLDSDTFTKAYQRMVLDAVTLNNLEIFLNGTNGSTEGTLLERVDTCHT PFGKRLLKQWLCAPLCNHYAINDRLDAIEDLMVVPDKISEVVELLKKLPD LERLLSKIHNVGSPLKSQNHPDSRAIMYEETTYSKKKIIDFLSALEGFKV MCKIIGIMEEVADGFKSKILKQVISLQTKNPEGRFPDLTVELNRWDTAFD HEKARKTGLITPKAGFDSDYDQALADIRENEQSLLEYLEKQRNRIGCRTI VYWGIGRNRYQLEIPENFTTRNLPEEYELKSTKKGCKRYWTKTIEKKLAN LINAEERRDVSLKDCMRRLFYNFDKNYKDWQSAVECIAVLDVLLCLANYS RGGDGPMCRPVILLPEDTPPFLELKGSRHPCITKDDFIPNDILIGCEEEE QENGKAYCVLVTGPNMGGKSTLMRQAGLLAVMAQMGCYVPAEVCRLTPID RVFTRLGASDRSTFFVELSETASILMHATAHSLVLVDELGRGTATFDGTA IANAVVKELAETIKCRTLFSTHYHSLVEDYSQNVAVRLGHMACMVENETI TFLYKFIKGACPKSYGFNAARLANLPEEVIQKGHRKAREFEKMNQSLRLF REVCLASERSDAEAVHKLLTLIKEL

Ligand information >8ag6 Chain F (length=25) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] gcaccgagcttgatcctcgatgatc

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 8ag6 Unexpected moves: a conformational change in MutS alpha enables high-affinity DNA mismatch binding. Resolution 2.8 Å Binding residue (original residue number in PDB) F432 L449 V450 M452 K453 G460 P462 R468 Y469 K1000 K1001 R1005 Binding residue (residue number reindexed from 1) F74 L91 V92 M94 K95 G102 P104 R110 Y111 K633 K634 R638

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0000287 magnesium ion binding GO:0000400 four-way junction DNA binding GO:0003677 DNA binding GO:0003682 chromatin binding GO:0003684 damaged DNA binding GO:0003690 double-stranded DNA binding GO:0005515 protein binding GO:0005524 ATP binding GO:0008094 ATP-dependent activity, acting on DNA GO:0019899 enzyme binding GO:0030983 mismatched DNA binding GO:0032137 guanine/thymine mispair binding GO:0032142 single guanine insertion binding GO:0032143 single thymine insertion binding GO:0032357 oxidized purine DNA binding GO:0032405 MutLalpha complex binding GO:0035064 methylated histone binding GO:0042803 protein homodimerization activity GO:0043531 ADP binding GO:0140664 ATP-dependent DNA damage sensor activity

	Biological Process
GO:0000710	meiotic mismatch repair
GO:0006281	DNA repair
GO:0006298	mismatch repair
GO:0006974	DNA damage response
GO:0007283	spermatogenesis
GO:0008340	determination of adult lifespan
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009411	response to UV
GO:0016446	somatic hypermutation of immunoglobulin genes
GO:0016447	somatic recombination of immunoglobulin gene segments
GO:0043570	maintenance of DNA repeat elements
GO:0045190	isotype switching
GO:0045910	negative regulation of DNA recombination
GO:0051096	positive regulation of helicase activity
GO:0097193	intrinsic apoptotic signaling pathway

	Cellular Component
GO:0000785	chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0032301	MutSalpha complex
GO:0043231	intracellular membrane-bounded organelle

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