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BioLiP

Structure of PDB 3twv Chain B Binding Site BS02

Receptor Information
>3twv Chain B (length=157) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYN
RVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV
ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDT
DIQDLLR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3twv Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
Resolution2.301 Å
Binding residue
(original residue number in PDB)		R525 S527 F532 G535 Y536 L560 N565 Y569 H571 D589 W591 F593 E598 K604
Binding residue
(residue number reindexed from 1)		R38 S40 F45 G48 Y49 L73 N78 Y82 H84 D102 W104 F106 E111 K117
Enzymatic activity
Enzyme Commision number 2.4.2.-
2.4.2.30: NAD(+) ADP-ribosyltransferase.
External links
PDB RCSB:3twv, PDBe:3twv, PDBj:3twv
PDBsum3twv
PubMed22153077
UniProtQ9H2K2|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)

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