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Structure of PDB 7wrf Chain A Binding Site BS02

Receptor Information >7wrf Chain A (length=930) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] AFGDIQFGKYLRLSCDTDSETLYELLTQHWHLKTPNLVISVTGGAKNFAL KPRMRKIFSRLIYIAQSKGAWILTGGTHYGLMKYIGEVVRDNTISRNSEE NIVAIGIAAWGMVSNRDTLIDEGHFSAYILDNNHTHLLLVDNGCHGHPTV EAKLRNQLEKYISERTSQDSNYGGKIPIVCFAQGGGRETLKAINTSVKSK IPCVVVEGSGQIADVIASLVTSSMVKEKLVRFLPRTVSRLPEEEIESWIK WLKEILESSHLLTVIKMEEAGDEIVSNAISYALYKAFSTNEQDKDNWNGQ LKLLLEWNQLDLASDEIFTNDRRWESADLQEVMFTALIKDRPKFVRLFLE NGLNLQKFLTNEVLTELFSTHFSTLVYRNLQIAKNSYNDALLTFVWKLVA NFRRRHPLQALFIWAILQNKKELSKVIWEQTKGCTLAALGASKLLKTLAK VKNDINAAGESEELANEYETRAVELFTECYSNDEDLAEQLLVYSCEAWGG SNCLELAVEATDQHFIAQPGVQNFLSKQWYGEISRDTKNWKIILCLFIIP LVGCGLVSFRKKLLWYYVAFFTSPFVVFSWNVVFYIAFLLLFAYVLLMDF HSVPHTPELILYALVFVLFCDEVRQWYMNGVNYFTDLWNVMDTLGLFYFI AGIVFRLHSSNKSSLYSGRVIFCLDYIIFTLRLIHIFTVSRNLGPKIIML QRMLIDVFFFLFLFAVWMVAFGVARQGILRQNEQRWRWIFRSVIYEPYLA MFGQVPSDVDSTTYDFSHCTFSGNESKPLCVELDEHNLPRFPEWITIPLV CIYMLSTNILLVNLLVAMFGYTVGIVQENNDQVWKFQRYFLVQEYCNRLN IPFPFVVFAYFYMVVKKCFKFRNEDNETLAWEGVMKENYLVKINTKANDN SEEMRHRFRQLDSKLNDLKSLLKEIANNIK

Ligand information Ligand ID KX7 InChI InChI=1S/C16H13N3O4/c20-15-7-2-1-6-14(15)18-9-8-13(17-16(18)21)11-4-3-5-12(10-11)19(22)23/h1-8,10,20H,9H2,(H,17,21) InChIKey RCEFMOGVOYEGJN-UHFFFAOYSA-N SMILES Software SMILES OpenEye OEToolkits 2.0.7 c1ccc(c(c1)N2CC=C(NC2=O)c3cccc(c3)[N+](=O)[O-])O CACTVS 3.385 Oc1ccccc1N2CC=C(NC2=O)c3cccc(c3)[N+]([O-])=O ACDLabs 12.01 C1C=C(NC(N1c2ccccc2O)=O)c3cc(ccc3)[N+]([O-])=O Formula C16 H13 N3 O4 Name Icilin; 3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one ChEMBL CHEMBL258405 DrugBank ZINC ZINC000000620751 PDB chain 7wrf Chain A Residue 1203 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 7wrf Structures of a mammalian TRPM8 in closed state. Resolution 3.04 Å Binding residue (original residue number in PDB) N741 V742 L778 D802 L806 F839 R842 I846 Binding residue (residue number reindexed from 1) N581 V582 L618 D642 L646 F679 R682 I686 Annotation score 1

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0005216 monoatomic ion channel activity GO:0005261 monoatomic cation channel activity GO:0005262 calcium channel activity GO:0005515 protein binding GO:0042802 identical protein binding

	Biological Process
GO:0006811	monoatomic ion transport
GO:0006816	calcium ion transport
GO:0006874	intracellular calcium ion homeostasis
GO:0009266	response to temperature stimulus
GO:0009409	response to cold
GO:0034220	monoatomic ion transmembrane transport
GO:0050955	thermoception
GO:0055085	transmembrane transport
GO:0070588	calcium ion transmembrane transport
GO:0120162	positive regulation of cold-induced thermogenesis

	Cellular Component
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0044853	plasma membrane raft
GO:0045121	membrane raft

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