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Structure of PDB 7wb8 Chain A Binding Site BS02

Receptor Information >7wb8 Chain A (length=223) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAHCYKSGIQVRL GEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLNSRV ASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKS AYPGQITSNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQK NKPGVYTKVCNYVSWIKQTIASN

Ligand information Ligand ID CA InChI InChI=1S/Ca/q+2 InChIKey BHPQYMZQTOCNFJ-UHFFFAOYSA-N SMILES Software SMILES CACTVS 3.341 [Ca++] ACDLabs 10.04 OpenEye OEToolkits 1.5.0 [Ca+2] Formula Ca Name CALCIUM ION ChEMBL DrugBank DB14577 ZINC PDB chain 7wb8 Chain A Residue 303 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 7wb8 In situ crystal data-collection and ligand-screening system at SPring-8. Resolution 1.38 Å Binding residue (original residue number in PDB) E75 N77 V80 E85 Binding residue (residue number reindexed from 1) E52 N54 V57 E62 Annotation score 4

Enzymatic activity Enzyme Commision number 3.4.21.4: trypsin.

Gene Ontology Molecular Function GO:0004175 endopeptidase activity GO:0004252 serine-type endopeptidase activity GO:0005515 protein binding GO:0008236 serine-type peptidase activity GO:0046872 metal ion binding GO:0097655 serpin family protein binding

	Biological Process
GO:0006508	proteolysis
GO:0007586	digestion

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0097180	serine protease inhibitor complex

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