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Structure of PDB 7eax Chain A Binding Site BS02

Receptor Information >7eax Chain A (length=194) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] SVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQL WVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLI RVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGG MNRRPILTIITLEDSSGNLLGRNSFEMRVCACPGRDRRTEEENL

Ligand information Ligand ID SB InChI InChI=1S/Sb/q+3 InChIKey FAWGZAFXDJGWBB-UHFFFAOYSA-N SMILES Software SMILES CACTVS 3.370 OpenEye OEToolkits 1.7.2 [Sb+3] Formula Sb Name ANTIMONY (III) ION ChEMBL DrugBank ZINC PDB chain 7eax Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 7eax Repurposing antiparasitic antimonials to noncovalently rescue temperature-sensitive p53 mutations. Resolution 2.55 Å Binding residue (original residue number in PDB) C124 M133 F134 C135 C141 Binding residue (residue number reindexed from 1) C29 M38 F39 C40 C46 Annotation score 1

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0000976 transcription cis-regulatory region binding GO:0003677 DNA binding GO:0003700 DNA-binding transcription factor activity

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0006915	apoptotic process

	Cellular Component
GO:0005634	nucleus

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