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BioLiP

Structure of PDB 4x9e Chain A Binding Site BS02

Receptor Information
>4x9e Chain A (length=499) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAQIDFRKKINWHRRYRSPQGVKTEHEILRIFESDRGRIINSPAIRRLQQ
KTQVFPLNAAVRTRLTHSMEVQQVGRYIAKEILSRLKELKLLEAYGLDEL
TGPFESIVEMSCLMHDIGNPPFGHFGEAAINDWFRQRLHPEDAESQPLTD
DRCSVAALRLRDGEEPLNELRRKIRQDLCHFEGNAQGIRLVHTLMRMNLT
WAQVGGILKYTRPAWWRGETPETHHYLMKKPGYYLSEEAYIARLRKELNL
ALYSRFPLTWIMEAADDISYCVADLEDAVEKRIFTVEQLYHHLHEAWGQH
EKGSLFSLVVENAWEKSRSNSTEDQFFMYLRVNTLNKLVPYAAQRFIDNL
PAIFAGTFNHALLEDASECSDLLKLYKNVAVKHVFSHPDVERLELQGYRV
ISGLLEIYRPLLSLSLSDFTELVEKERVKRFPIESRLFHKLSTRHRLAYV
EAVSKLPSDSPEFPLWEYYYRCRLLQDYISGMTDLYAWDEYRRLMAVEQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4x9e Structure of Escherichia coli dGTP Triphosphohydrolase: A HEXAMERIC ENZYME WITH DNA EFFECTOR MOLECULES.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		Y79 M334 Y335 V338
Binding residue
(residue number reindexed from 1)		Y77 M328 Y329 V332
Enzymatic activity
Catalytic site (original residue number in PDB) H69 H117 D118 D268 R442
Catalytic site (residue number reindexed from 1) H67 H115 D116 D266 R436
Enzyme Commision number 3.1.5.1: dGTPase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003697 single-stranded DNA binding
GO:0003924 GTPase activity
GO:0008832 dGTPase activity
GO:0016787 hydrolase activity
GO:0016793 triphosphoric monoester hydrolase activity
GO:0030145 manganese ion binding
GO:0042802 identical protein binding
GO:0050897 cobalt ion binding
Biological Process
GO:0006203 dGTP catabolic process
GO:0015949 nucleobase-containing small molecule interconversion
GO:0043099 pyrimidine deoxyribonucleoside salvage

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Molecular Function
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Biological Process
External links
PDB RCSB:4x9e, PDBe:4x9e, PDBj:4x9e
PDBsum4x9e
PubMed25694425
UniProtP15723|DGTP_ECOLI Deoxyguanosinetriphosphate triphosphohydrolase (Gene Name=dgt)

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