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Structure of PDB 4w5t Chain A Binding Site BS02

Receptor Information >4w5t Chain A (length=807) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] AFKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIKPEKCPRRVN REIVEHMVQHFKTQIFGDRKPVFDGRKNLYTAMPLPIGRDKVELEVTLPI FKVSIKWVSCVSLQALHDALSGRLPSVPFETIQALDVVMRHLPSMRYTPV GRSFFTASEGCSNPLGGGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKA QPVIEFVCEVLDFKSIEEQQKPLTDSQRVKFTKEIKGLKVEITHKRKYRV CNVTRRPASHQTFPLVECTVAQYFKDRHKLVLRYPHLPCLQVGQEQKHTY LPLEVCNIVAGQRCIKKLTDNQTSTMIRATARSAPDRQEEISKLMRSADF NTDPYVREFGIMVKDEMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMR NKQFHTGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGMPIQGQ PCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILPGKTPVYAEVKRVGDT VLGMATQCVQMKNVQRTTPQTLSNLCLKINVKLGGVNNILLPQGRPPVFQ QPVIFLGADVTHPPAGDGKKPSIAAVVGSMDAHPNRYCATVRVQQHRQEI IQDLAAMVRELLIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIR EACIKLEKDYQPGITFIVVQKRHHTRLFCTDKNERVGKSGNIPAGTTVDT KITHPTEFDFYLCSHAGIQGTSRPSHYHVLWDDNRFSSDELQILTYQLCH TYVRCTRSVSIPAPAYYAHLVAFRARYHLVDKEGRDHQALAKAVQVHQDT LRTMYFA

Ligand information >4w5t Chain D (length=10) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] acaugugaaa ..........

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 4w5t Gene regulation. Structural basis for microRNA targeting. Resolution 2.5 Å Binding residue (original residue number in PDB) D358 T361 S362 R438 P557 Q558 S561 F811 Binding residue (residue number reindexed from 1) D320 T323 S324 R400 P519 Q520 S523 F773

Enzymatic activity Enzyme Commision number 3.1.26.n2: argonaute-2.

Gene Ontology Molecular Function GO:0000340 RNA 7-methylguanosine cap binding GO:0000993 RNA polymerase II complex binding GO:0001046 core promoter sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003723 RNA binding GO:0003725 double-stranded RNA binding GO:0003727 single-stranded RNA binding GO:0003729 mRNA binding GO:0003743 translation initiation factor activity GO:0004519 endonuclease activity GO:0004521 RNA endonuclease activity GO:0005515 protein binding GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters GO:0035197 siRNA binding GO:0035198 miRNA binding GO:0035925 mRNA 3'-UTR AU-rich region binding GO:0046872 metal ion binding GO:0061980 regulatory RNA binding GO:0070551 endoribonuclease activity, cleaving siRNA-paired mRNA GO:0090624 endoribonuclease activity, cleaving miRNA-paired mRNA GO:0098808 mRNA cap binding

	Biological Process
GO:0006355	regulation of DNA-templated transcription
GO:0006412	translation
GO:0006413	translational initiation
GO:0006417	regulation of translation
GO:0009791	post-embryonic development
GO:0010501	RNA secondary structure unwinding
GO:0010586	miRNA metabolic process
GO:0010628	positive regulation of gene expression
GO:0030422	siRNA processing
GO:0031047	regulatory ncRNA-mediated gene silencing
GO:0031054	pre-miRNA processing
GO:0033962	P-body assembly
GO:0035194	regulatory ncRNA-mediated post-transcriptional gene silencing
GO:0035196	miRNA processing
GO:0035278	miRNA-mediated gene silencing by inhibition of translation
GO:0035279	miRNA-mediated gene silencing by mRNA destabilization
GO:0042985	negative regulation of amyloid precursor protein biosynthetic process
GO:0045727	positive regulation of translation
GO:0045766	positive regulation of angiogenesis
GO:0045944	positive regulation of transcription by RNA polymerase II
GO:0045947	negative regulation of translational initiation
GO:0060213	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0070922	RISC complex assembly
GO:0090128	regulation of synapse maturation
GO:0090625	siRNA-mediated gene silencing by mRNA destabilization
GO:1900153	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:1901165	positive regulation of trophoblast cell migration

	Cellular Component
GO:0000932	P-body
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0016442	RISC complex
GO:0030425	dendrite
GO:0036464	cytoplasmic ribonucleoprotein granule
GO:0043232	intracellular non-membrane-bounded organelle
GO:0070062	extracellular exosome
GO:0070578	RISC-loading complex
GO:0098794	postsynapse
GO:0098978	glutamatergic synapse
GO:1990904	ribonucleoprotein complex

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