BioLiP

Structure of PDB 4qzi Chain A Binding Site BS02

Receptor Information

>4qzi Chain A (length=336) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KKISQYACQRRTTLNNYNQLFTDALDILAENDELRENEGSCLAFMRASSV
LKSLPFPITSMKDTEGIPCLGDKVKSIIEGIIEDGESSEAKAVLNDERYK
SFKLFTSVFGVGLKTAEKWFRMGFRTLSKIQSDKSLRFTQMQKAGFLYYE
DLVSCVNRPEAEAVSMLVKEAVVTFLPDALVTMTGGFRRGKMTGHDVDFL
ITSPEATEDEEQQLLHKVTDFWKQQGLLLYCDILEAQKCFLILKLDHGRV
GKGWKAIRVDLVMCPYDRRAFALLGWTGSRQFERDLRRYATHERKMMLDN
HALYDRTKRVFLEAESEEEIFAHLGLDYIEPWERNA

Ligand information

>4qzi Chain T (length=8) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tttttggg

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4qzi Structural basis for a novel mechanism of DNA bridging and alignment in eukaryotic DSB DNA repair.
Resolution	2.65 Å
Binding residue (original residue number in PDB)	L189 R193 R458 H466
Binding residue (residue number reindexed from 1)	L42 R46 R284 H292

Enzymatic activity

Catalytic site (original residue number in PDB)	D343 D345 D434
Catalytic site (residue number reindexed from 1)	D196 D198 D260
Enzyme Commision number	2.7.7.31: DNA nucleotidylexotransferase. 3.1.11.-

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0016779	nucleotidyltransferase activity
GO:0034061	DNA polymerase activity

	Biological Process
GO:0006281	DNA repair

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Molecular Function

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Biological Process

PDB	RCSB:4qzi, PDBe:4qzi, PDBj:4qzi
PDBsum	4qzi
PubMed	25762590
UniProt	P09838\|TDT_MOUSE DNA nucleotidylexotransferase (Gene Name=Dntt)