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Structure of PDB 2rba Chain A Binding Site BS02

Receptor Information
>2rba Chain A (length=182) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLPDILTFNLDIVIIGINPGLMAAYKGHHYPGPGNHFWKCLFMSGLSEVQ
LNHMDDHTLPGKYGIGFTNMVERTTPGSKDLSSKEFREGGRILVQKLQKY
QPRIAVFNGKCIYEIFSKEVFGVKVKNLEFGLQPHKIPDTETLCYVMPSS
SARCAQFPRAQDKVHYYIKLKDLRDQLKGIER
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2rba Crystal structure of human thymine DNA glycosylase bound to DNA elucidates sequence-specific mismatch recognition.
Resolution2.79 Å
Binding residue
(original residue number in PDB)		N140 N157 S200 G231 K232 S271 S273 R275 C276 Q278
Binding residue
(residue number reindexed from 1)		N18 N35 S78 G109 K110 S149 S151 R153 C154 Q156
Enzymatic activity
Catalytic site (original residue number in PDB) H151
Catalytic site (residue number reindexed from 1) H29
Enzyme Commision number 3.2.2.29: thymine-DNA glycosylase.
Gene Ontology
Molecular Function
GO:0000700 mismatch base pair DNA N-glycosylase activity
Biological Process
GO:0006285 base-excision repair, AP site formation

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Molecular Function
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Biological Process
External links
PDB RCSB:2rba, PDBe:2rba, PDBj:2rba
PDBsum2rba
PubMed18587051
UniProtQ13569|TDG_HUMAN G/T mismatch-specific thymine DNA glycosylase (Gene Name=TDG)

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