Online Services

●I-TASSER ●I-TASSER-MTD ●C-I-TASSER ●CR-I-TASSER ●QUARK ●C-QUARK ●LOMETS ●MUSTER ●CEthreader ●SEGMER ●DeepFold ●DeepFoldRNA ●FoldDesign ●COFACTOR ●COACH ●MetaGO ●TripletGO ●IonCom ●FG-MD ●ModRefiner ●REMO ●DEMO ●DEMO-EM ●SPRING ●COTH ●Threpp ●PEPPI ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●BindProf ●BindProfX ●SSIPe ●GPCR-I-TASSER ●MAGELLAN ●ResQ ●STRUM ●DAMpred

●TM-score ●TM-align ●US-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●TripletRes ●DeepPotential ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●GPU-I-TASSER

●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14

Structure of PDB 1mf0 Chain A Binding Site BS02

Receptor Information >1mf0 Chain A (length=431) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] AATGSRVTVVLGAQWGDEGKGKVVDLLATDADIVSRCQGGNNAGHTVVVD GKEYDFHLLPSGIINTKAVSFIGNGVVIHLPGLFEEAEKNEKKGLKDWEK RLIISDRAHLVFDFHQAVDGLQEVQRQAQEGKNIGTTKKGIGPTYSSKAA RTGLRICDLLSDFDEFSARFKNLAHQHQSMFPTLEIDVEGQLKRLKGFAE RIRPMVRDGVYFMYEALHGPPKKVLVEGANAALLDIDFGTYPFVTSSNCT VGGVCTGLGIPPQNIGDVYGVVKAYTTRVGIGAFPTEQINEIGDLLQNRG HEWGVTTGRKRRCGWLDLMILRYAHMVNGFTALALTKLDILDVLSEIKVG ISYKLNGKRIPYFPANQEILQKVEVEYETLPGWKADTTGARKWEDLPPQA QSYVRFVENHMGVAVKWVGVGKSRESMIQLF

Ligand information Ligand ID PO4 InChI InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3 InChIKey NBIIXXVUZAFLBC-UHFFFAOYSA-K SMILES Software SMILES CACTVS 3.341 [O-][P]([O-])([O-])=O ACDLabs 10.04 [O-]P([O-])([O-])=O OpenEye OEToolkits 1.5.0 [O-]P(=O)([O-])[O-] Formula O4 P Name PHOSPHATE ION ChEMBL DrugBank DB14523 ZINC PDB chain 1mf0 Chain A Residue 1451 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1mf0 Feedback inhibition and product complexes of recombinant mouse muscle adenylosuccinate synthetase. Resolution 2.5 Å Binding residue (original residue number in PDB) G42 D43 K46 A69 G70 H71 N256 Binding residue (residue number reindexed from 1) G16 D17 K20 A43 G44 H45 N230 Annotation score 1

Enzymatic activity Catalytic site (original residue number in PDB) D43 K46 G70 H71 N256 Catalytic site (residue number reindexed from 1) D17 K20 G44 H45 N230 Enzyme Commision number 6.3.4.4: adenylosuccinate synthase.

Gene Ontology Molecular Function GO:0000166 nucleotide binding GO:0000287 magnesium ion binding GO:0004019 adenylosuccinate synthase activity GO:0005515 protein binding GO:0005525 GTP binding GO:0016874 ligase activity GO:0046872 metal ion binding

	Biological Process
GO:0006163	purine nucleotide metabolic process
GO:0006164	purine nucleotide biosynthetic process
GO:0006167	AMP biosynthetic process
GO:0044208	'de novo' AMP biosynthetic process
GO:0044209	AMP salvage

	Cellular Component
GO:0005737	cytoplasm
GO:0016020	membrane

View graph for Molecular Function

View graph for Biological Process

View graph for Cellular Component