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Structure of PDB 8iod Chain R Binding Site BS01

Receptor Information >8iod Chain R (length=270) Species: 9606,392809 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] GIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVS MSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAI AVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYV ILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGATSMQGAVTVTM LLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDP LIYAFRSQEMRKTFKEIICC

Ligand information >8iod Chain L (length=7) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] PDPWRWK

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 8iod Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors. Resolution 2.59 Å Binding residue (original residue number in PDB) I96 V111 D115 D119 I122 I178 S181 I187 L190 F254 M261 F277 L281 Binding residue (residue number reindexed from 1) I60 V75 D79 D83 I86 I142 S145 I151 L154 F212 M219 F235 L239

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0004930 G protein-coupled receptor activity GO:0004977 melanocortin receptor activity GO:0005515 protein binding GO:0042562 hormone binding

	Biological Process
GO:0007186	G protein-coupled receptor signaling pathway
GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007189	adenylate cyclase-activating G protein-coupled receptor signaling pathway
GO:0019222	regulation of metabolic process

	Cellular Component
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0016020	membrane

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