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Structure of PDB 5iyc Chain M Binding Site BS01

Receptor Information >5iyc Chain M (length=310) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] LDALPRVTCPNHPDAILVEDYRAGDMICPECGLVVGDRVIDVGSEWRTFS NDKATKDPSRVGDSQNPLLSDGDLSTMIGKGTGAASFDEFGNSKYQNRRT MSSSDRAMMNAFKEITTMADRINLPRNIVDRTNNLFKQVYEQKSLKGRAN DAIASACLYIACRQEGVPRTFKEICAVSRISKKEIGRCFKLILKALETSV DLITTGDFMSRFCSNLCLPKQVQMAATHIARKAVELDLVPGRSPISVAAA AIYMASQASAEKRTQKEIGDIAGVADVTIRQSYRLIYPRAPDLFPTDFKF DTPVDKLPQL

Ligand information >5iyc Chain X (length=80) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] gaagggcgcctataaaagggggtgggggcgtttttttttttttttttttt cgaacactcgagccgagcagacgtgcctac

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 5iyc Near-atomic resolution visualization of human transcription promoter opening. Resolution 3.9 Å Binding residue (original residue number in PDB) K86 K152 K189 K196 R286 R290 Binding residue (residue number reindexed from 1) K80 K146 K183 K190 R280 R284

Enzymatic activity Enzyme Commision number 2.3.1.48: histone acetyltransferase.

Gene Ontology Molecular Function GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding GO:0000993 RNA polymerase II complex binding GO:0003677 DNA binding GO:0004402 histone acetyltransferase activity GO:0005515 protein binding GO:0008270 zinc ion binding GO:0016251 RNA polymerase II general transcription initiation factor activity GO:0016407 acetyltransferase activity GO:0016746 acyltransferase activity GO:0017025 TBP-class protein binding GO:0046872 metal ion binding GO:0046966 nuclear thyroid hormone receptor binding GO:0061733 peptide-lysine-N-acetyltransferase activity GO:0140297 DNA-binding transcription factor binding GO:1990841 promoter-specific chromatin binding

	Biological Process
GO:0001174	transcriptional start site selection at RNA polymerase II promoter
GO:0006338	chromatin remodeling
GO:0006352	DNA-templated transcription initiation
GO:0006366	transcription by RNA polymerase II
GO:0006367	transcription initiation at RNA polymerase II promoter
GO:0006473	protein acetylation
GO:0010467	gene expression
GO:0019083	viral transcription
GO:0051123	RNA polymerase II preinitiation complex assembly
GO:0051177	meiotic sister chromatid cohesion
GO:0051225	spindle assembly
GO:0051276	chromosome organization
GO:0070897	transcription preinitiation complex assembly
GO:1904798	positive regulation of core promoter binding
GO:1990114	RNA polymerase II core complex assembly

	Cellular Component
GO:0000776	kinetochore
GO:0000793	condensed chromosome
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005669	transcription factor TFIID complex
GO:0005694	chromosome
GO:0016604	nuclear body
GO:0032153	cell division site
GO:0032993	protein-DNA complex
GO:0042585	germinal vesicle
GO:0090575	RNA polymerase II transcription regulator complex
GO:0097550	transcription preinitiation complex

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