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Structure of PDB 1t8y Chain E Binding Site BS01

Receptor Information >1t8y Chain E (length=461) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] LTPAQALDKLDALYEQSVVALRNAIGNYITSGELPDENARKQGLFVYPSL TVTWDGSTTNPPKTRAFGRFTHAGSYTTTITRPTLFRSYLNEQLTLLYQD YGAHISVQPSQHEIPYPYVIDGSELTLDRSMSAGLTRYFPTTELFSPLSH FDARRVDFSLARLRHYTGTPVEHFQPFVLFTNYTRYVDEFVRWGCSQILD PDSPYIALSCAGGNWITAETEAPEEAISDLAWKKHQMPAWHLITADGQGI TLVNIGVGPSNAKTICDHLAVLRPDVWLMIGHCGGLRESQAIGDYVLAHA YLRDDHVLDAVLPPDIPIPSIAEVQRALYDATKLVSGRPGEEVKQRLRTG TVVTTDDRNWELRYSASALRFNLSRAVAIDMESATIAAQGYRFRVPYGTL LCVSDKPLHGEIKLPGQANRFYEGAISEHLQIGIRAIDLLRAEGDRLHSR KLRTFNEPPFR

Ligand information Ligand ID PO4 InChI InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3 InChIKey NBIIXXVUZAFLBC-UHFFFAOYSA-K SMILES Software SMILES CACTVS 3.341 [O-][P]([O-])([O-])=O ACDLabs 10.04 [O-]P([O-])([O-])=O OpenEye OEToolkits 1.5.0 [O-]P(=O)([O-])[O-] Formula O4 P Name PHOSPHATE ION ChEMBL DrugBank DB14523 ZINC PDB chain 1t8y Chain D Residue 505 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 1t8y Structure of Escherichia coli AMP Nucleosidase Reveals Similarity to Nucleoside Phosphorylases Resolution 3.0 Å Binding residue (original residue number in PDB) K367 R371 T372 Binding residue (residue number reindexed from 1) K344 R348 T349 Annotation score 1

Enzymatic activity Enzyme Commision number 3.2.2.4: AMP nucleosidase.

Gene Ontology Molecular Function GO:0003824 catalytic activity GO:0008714 AMP nucleosidase activity GO:0016787 hydrolase activity

	Biological Process
GO:0009116	nucleoside metabolic process
GO:0044209	AMP salvage
GO:0046033	AMP metabolic process

	Cellular Component
GO:0005737	cytoplasm
GO:0005829	cytosol

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