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BioLiP

Structure of PDB 6w8j Chain D Binding Site BS01

Receptor Information
>6w8j Chain D (length=285) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AEKRKPIRVLSLFDGIATGLLVLKDLGIQVDRYIASEVCEDSITVGMVRH
QGKIMYVGDVRSVTQKHIQEWGPFDLVIGGSPCNDLSIVNPARKGLYEGT
GRLFFEFYRLLHDARPKEGDDRPFFWLFENVVAMGVSDKRDISRFLESNP
VMIDAKEVSAAHRARYFWGNLPGMNRPLASTVNDKLELQECLEHGRIAKF
SKVRTITTRSNSIKQGKDQHFPVFMNEKEDILWCTEMERVFGFPVHYTDV
SNMSHLARQRLLGRSWSVPVIRHLFAPLKEYFACV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6w8j Structural basis for impairment of DNA methylation by the DNMT3A R882H mutation.
Resolution2.445 Å
Binding residue
(original residue number in PDB)		S708 C710 N711 V716 N717 E756 V758 R792 R831 T832 T834 T835 R836 G890 R891
Binding residue
(residue number reindexed from 1)		S81 C83 N84 V89 N90 E129 V131 R165 R204 T205 T207 T208 R209 G263 R264
Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:6w8j, PDBe:6w8j, PDBj:6w8j
PDBsum6w8j
PubMed32385248
UniProtQ9Y6K1|DNM3A_HUMAN DNA (cytosine-5)-methyltransferase 3A (Gene Name=DNMT3A)

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