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Structure of PDB 5yqg Chain D Binding Site BS01

Receptor Information >5yqg Chain D (length=227) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] MGDREQLLQRARLAEQAERYDDMASAMKAVTELNEPLSNEDRNLLSVAYK NVVGARRSSWRVISSIEQKTMANEKKLEKVKAYREKIEKELETVCNDVLA LLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVASGEKKNSVVEASEA AYKEAFEISKEHMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFD DAIAELDSYKDSTLIMQLLRDNLTLWT

Ligand information >5yqg Chain F (length=19) Species: 10090 (Mus musculus) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure] QGSFRSQKMSPFKRQLSLR

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 5yqg Structural determinants controlling 14-3-3 recruitment to the endocytic adaptor Numb and dissociation of the Numb/alpha-adaptin complex. Resolution 2.1 Å Binding residue (original residue number in PDB) K50 R57 R132 Y133 L177 N178 V181 N229 Binding residue (residue number reindexed from 1) K50 R57 R130 Y131 L175 N176 V179 N222

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0003779 actin binding GO:0005515 protein binding GO:0017080 sodium channel regulator activity GO:0019899 enzyme binding GO:0019904 protein domain specific binding GO:0035259 nuclear glucocorticoid receptor binding GO:0042802 identical protein binding GO:0044325 transmembrane transporter binding GO:0046982 protein heterodimerization activity

	Biological Process
GO:0002028	regulation of sodium ion transport
GO:0006713	glucocorticoid catabolic process
GO:0006886	intracellular protein transport
GO:0007010	cytoskeleton organization
GO:0007088	regulation of mitotic nuclear division
GO:0042921	nuclear receptor-mediated glucocorticoid signaling pathway
GO:0043066	negative regulation of apoptotic process
GO:0045184	establishment of protein localization
GO:0045893	positive regulation of DNA-templated transcription
GO:0050774	negative regulation of dendrite morphogenesis
GO:0086010	membrane depolarization during action potential
GO:0099171	presynaptic modulation of chemical synaptic transmission
GO:2000649	regulation of sodium ion transmembrane transporter activity

	Cellular Component
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0014704	intercalated disc
GO:0098793	presynapse
GO:0098978	glutamatergic synapse
GO:0150048	cerebellar granule cell to Purkinje cell synapse

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