BioLiP

Structure of PDB 5hro Chain D Binding Site BS01

Receptor Information

>5hro Chain D (length=412) Species: 11678 (Human immunodeficiency virus type 1 BH10) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPE
NPYNTPVFAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKK
KSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGW
KGSPAIFQSSMTKILEPFKKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIE
ELRQHLLRWGLTTPGYELHPDKWTVQPIVLPEKDSWTVNDIQKLVGKLNW
ASQIYPGIKVRQLSKLLRGTKALTEVIPLTEEAELELAENREILKEPVHG
VYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGAHTNDVK
QLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEF
VNTPPLVKLWYQ

Ligand information

>5hro Chain F (length=35) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tacccccccttcggtgctttgcaccgaaggggggg

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5hro Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet.
Resolution	2.75 Å
Binding residue (original residue number in PDB)	K22 K395
Binding residue (residue number reindexed from 1)	K19 K379

Enzymatic activity

Enzyme Commision number

2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.

Gene Ontology

	Molecular Function
GO:0003964	RNA-directed DNA polymerase activity

	Biological Process
GO:0006278	RNA-templated DNA biosynthetic process

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Molecular Function

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Biological Process

PDB	RCSB:5hro, PDBe:5hro, PDBj:5hro
PDBsum	5hro
PubMed	27192549
UniProt	P03366\|POL_HV1B1 Gag-Pol polyprotein (Gene Name=gag-pol)