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BioLiP

Structure of PDB 4znx Chain D Binding Site BS01

Receptor Information

>4znx Chain D (length=57) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYIP
SNYVAPV

Ligand information

>4znx Chain E (length=10) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

APPLPPRNRP

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4znx The role of water molecules in the binding of class I and II peptides to the SH3 domain of the Fyn tyrosine kinase.
Resolution	2.1 Å
Binding residue (original residue number in PDB)	F87 S114 D118 W120 S135 P140
Binding residue (residue number reindexed from 1)	F3 S30 D34 W36 S51 P56

Enzymatic activity

Enzyme Commision number

2.7.10.2: non-specific protein-tyrosine kinase.

External links

PDB	RCSB:4znx, PDBe:4znx, PDBj:4znx
PDBsum	4znx
PubMed	27599862
UniProt	P06241\|FYN_HUMAN Tyrosine-protein kinase Fyn (Gene Name=FYN)

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