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Structure of PDB 8fww Chain C Binding Site BS01

Receptor Information >8fww Chain C (length=420) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] RSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI RLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFS KPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFV IARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKA LSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKI EYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKSNEEGIQRVLT SDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITI AILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAG LVLSVFVAVGEFLYKSKKNA

Ligand information Ligand ID 2J9 InChI InChI=1S/C10H11FN2O2S/c11-7-1-4-9-10(5-7)16(14,15)12-6-13(9)8-2-3-8/h1,4-5,8,12H,2-3,6H2 InChIKey FLTMTBPCYAZIKM-UHFFFAOYSA-N SMILES Software SMILES ACDLabs 12.01 Fc1ccc2c(c1)S(=O)(=O)NCN2C3CC3 CACTVS 3.385 Fc1ccc2N(CN[S](=O)(=O)c2c1)C3CC3 OpenEye OEToolkits 1.7.6 c1cc2c(cc1F)S(=O)(=O)NCN2C3CC3 Formula C10 H11 F N2 O2 S Name 4-cyclopropyl-7-fluoro-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide ChEMBL CHEMBL2441067 DrugBank ZINC ZINC000095921421 PDB chain 8fww Chain B Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 8fww Positive and negative allosteric modulation of GluK2 kainate receptors by BPAM344 and antiepileptic perampanel. Resolution 3.1 Å Binding residue (original residue number in PDB) I519 P532 S761 K762 G763 Binding residue (residue number reindexed from 1) I89 P102 S331 K332 G333 Annotation score 1

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0005216 monoatomic ion channel activity GO:0015276 ligand-gated monoatomic ion channel activity GO:0038023 signaling receptor activity

	Biological Process
GO:0006811	monoatomic ion transport

	Cellular Component
GO:0016020	membrane

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