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Structure of PDB 8b9y Chain C Binding Site BS01

Receptor Information >8b9y Chain C (length=330) Species: 5693 (Trypanosoma cruzi) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure] VQEFDPRNNVAPSMDALIGETPAVYLKRMNDTAATIVLKLECENPMASVK DRLAYAIYDKAEKEGKIIPGKSVIVEATSGNTGIALAHIGTIRGYKVIIV MPESMSIERRCLMRIFGAEVILTPAALGMKGALEAVNRIVSNNPDAVSAN QFATKYNAQIHEETTGPEIWRQTKGHVDCFVAGVGTGGTITGVARYLKSV GCGATIFAVEPAESPVLSGGKPGPHRIQGIGAGFVPEVFEAALVDEVIQV SGDEAIDTAQKLPRTDGIFCGFSGGANVYAALQIAKRPEMAGKTIVTVIP SYGERYLSTALYSSIKDEVFALKVLSAADI

Ligand information Ligand ID PLP InChI InChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14) InChIKey NGVDGCNFYWLIFO-UHFFFAOYSA-N SMILES Software SMILES CACTVS 3.341 Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O OpenEye OEToolkits 1.5.0 Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O ACDLabs 10.04 O=P(O)(O)OCc1cnc(c(O)c1C=O)C Formula C8 H10 N O6 P Name PYRIDOXAL-5'-PHOSPHATE; VITAMIN B6 Phosphate ChEMBL CHEMBL82202 DrugBank DB00114 ZINC ZINC000001532514 PDB chain 8b9y Chain C Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure Global view Local view Structure summary [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] [Spin on] [Spin off] [Reset] [High quality] [Low quality] [White background] [Black background] PDB 8b9y Cysteine synthase: multiple structures of a key enzyme in cysteine synthesis and a potential drug target for Chagas disease and leishmaniasis. Resolution 1.8 Å Binding residue (original residue number in PDB) K64 N95 G199 T200 G201 T203 G243 S287 P314 S315 Binding residue (residue number reindexed from 1) K50 N81 G185 T186 G187 T189 G229 S273 P300 S301 Annotation score 1

Enzymatic activity Enzyme Commision number ?

Gene Ontology Molecular Function GO:0004124 cysteine synthase activity

	Biological Process
GO:0006535	cysteine biosynthetic process from serine

	Cellular Component
GO:0005737	cytoplasm

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